Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain
文献类型：期刊论文
| 作者 | Zhang, Xu
|
| 刊名 | BRAIN
 |
| 出版日期 | 2012 |
| 卷号 | 135页码:391-403 |
| 关键词 | activin C inflammatory pain dorsal root ganglion extracellular signal-regulated kinase DORSAL-ROOT GANGLION GENE-RELATED PEPTIDE BONE MORPHOGENETIC PROTEINS SPINAL SUBARACHNOID SPACE SIGNAL-REGULATED KINASE FOLLISTATIN-LIKE 1 NEUROPATHIC PAIN SENSORY NEURONS LIVER-REGENERATION BETA-C |
| ISSN号 | 0006-8950 |
| 通讯作者 | Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,xu.zhang@ion.ac.cn |
| 英文摘要 | Emerging evidence suggests that the suppressive modulators released from nociceptive afferent neurons contribute to pain regulation. However, the suppressive modulators expressed in small-diameter neurons of the dorsal root ganglion remain to be further identified. The present study shows that the activin C expressed in small dorsal root ganglion neurons is required for suppressing inflammation-induced nociceptive responses. The expression of activin C in small dorsal root ganglion neurons of rats was markedly downregulated during the early days of peripheral inflammation induced by intraplantar injection of the complete Freund's adjuvant. Intrathecal treatment with the small interfering RNA targeting activin beta C or the antibodies against activin C could enhance the formalin-induced nociceptive responses, and impair the recovery from the complete Freund's adjuvant-induced thermal hyperalgesia. Intrathecally applied activin C could reduce nociceptive responses induced by formalin or complete Freund's adjuvant. Moreover, activin C was found to inhibit the inflammation-induced phosphorylation of extracellular signal-regulated kinase in the dorsal root ganglia and the dorsal spinal cord. Thus, activin C functions as an endogenous suppressor of inflammatory nociceptive transmission and may have a therapeutic potential for treatment of inflammatory pain. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[30870832, 30630029]; National Basic Research Program of China[2009CB522005, 2011CBA00400]; China Postdoctoral Science Foundation[20060400684] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1502]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_感觉系统研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, Xu. Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain[J]. BRAIN,2012,135:391-403. |
| APA | Zhang, Xu.(2012).Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain.BRAIN,135,391-403. |
| MLA | Zhang, Xu."Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain".BRAIN 135(2012):391-403. |
入库方式： OAI收割
来源：上海神经科学研究所
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