Follistatin-like 1 Suppresses Sensory Afferent Transmission by Activating Na+,K+-ATPase
文献类型：期刊论文
| 作者 | Zhang, Xu
|
| 刊名 | NEURON
 |
| 出版日期 | 2011 |
| 卷号 | 69期号:5页码:974-987 |
| 关键词 | DORSAL-ROOT GANGLIA PERIPHERAL NERVOUS-SYSTEM SYNAPTIC VESICLE SPINAL-CORD NA+/K+ PUMP NEURONS RAT PROTEIN EXPRESSION ISOFORMS |
| ISSN号 | 0896-6273 |
| 通讯作者 | Gao, XA (reprint author), Nanjing Univ, Model Anim Res Ctr, Nanjing 210061, Peoples R China,gaoxiang@nju.edu.cn ; xu.zhang@ion.ac.cn |
| 英文摘要 | Excitatory synaptic transmission is modulated by inhibitory neurotransmitters and neuromodulators. We found that the synaptic transmission of somatic sensory afferents can be rapidly regulated by a presynaptically secreted protein, follistatin-like 1 (FSTL1), which serves as a direct activator of Na+,K+-ATPase (NKA). The FSTL1 protein is highly expressed in small-diameter neurons of the dorsal root ganglion (DRG). It is transported to axon terminals via small translucent vesicles and secreted in both spontaneous and depolarization-induced manners. Biochemical assays showed that FSTL1 binds to the alpha 1 subunit of NKA and elevates NKA activity. Extracellular FSTL1 induced membrane hyperpolarization in cultured cells and inhibited afferent synaptic transmission in spinal cord slices by activating NKA. Genetic deletion of FSTL1 in small DRG neurons of mice resulted in enhanced afferent synaptic transmission and sensory hypersensitivity, which could be reduced by intrathecally applied FSTL1 protein. Thus, FSTL1-dependent activation of NKA regulates the threshold of somatic sensation. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | NNSFC[30630029, 30621062]; MOST[2011CBA00400, 2009CB522005, 2006AA020704]; [06R214160]; [2007KIP402] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1547]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_感觉系统研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, Xu. Follistatin-like 1 Suppresses Sensory Afferent Transmission by Activating Na+,K+-ATPase[J]. NEURON,2011,69(5):974-987. |
| APA | Zhang, Xu.(2011).Follistatin-like 1 Suppresses Sensory Afferent Transmission by Activating Na+,K+-ATPase.NEURON,69(5),974-987. |
| MLA | Zhang, Xu."Follistatin-like 1 Suppresses Sensory Afferent Transmission by Activating Na+,K+-ATPase".NEURON 69.5(2011):974-987. |
入库方式： OAI收割
来源：上海神经科学研究所
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