Potentiation of excitatory transmission in substantia gelatinosa neurons of rat spinal cord by inhibition of estrogen receptor alpha
文献类型：期刊论文
| 作者 | Zhang, Xu
|
| 刊名 | MOLECULAR PAIN
 |
| 出版日期 | 2010 |
| 卷号 | 6页码:92-92 |
| 关键词 | ROOT GANGLION NEURONS IMMUNOREACTIVE NEURONS SENSORY NEURONS DORSAL-HORN BRAIN-STEM AROMATASE BETA PAIN MECHANISMS EXPRESSION |
| ISSN号 | 1744-8069 |
| 通讯作者 | Li, KC (reprint author), Chinese Acad Sci, Inst Neurosci, Beijing 100864, Peoples R China,likaicheng@ion.ac.cn |
| 英文摘要 | Background: It has been shown that estrogen is synthesized in the spinal dorsal horn and plays a role in modulating pain transmission. One of the estrogen receptor (ER) subtypes, estrogen receptor alpha (ER alpha), is expressed in the spinal laminae I-V, including substantia gelatinosa (SG, lamina II). However, it is unclear how ERs are involved in the modulation of nociceptive transmission. Results: In the present study, a selective ER alpha antagonist, methyl-piperidino-pyrazole (MPP), was used to test the potential functional roles of spinal ER alpha in the nociceptive transmission. Using the whole-cell patch-clamp technique, we examined the effects of MPP on SG neurons in the dorsal root-attached spinal cord slice prepared from adult rats. We found that MPP increased glutamatergic excitatory postsynaptic currents (EPSCs) evoked by the stimulation of either A delta- or C-afferent fibers. Further studies showed that MPP treatment dose-dependently increased spontaneous EPSCs frequency in SG neurons, while not affecting the amplitude. In addition, the PKC was involved in the MPP-induced enhancement of synaptic transmission. Conclusions: These results suggest that the selective ER alpha antagonist MPP pre-synaptically facilitates the excitatory synaptic transmission to SG neurons. The nociceptive transmission evoked by A delta- and C-fiber stimulation could be potentiated by blocking ER alpha in the spinal neurons. Thus, the spinal estrogen may negatively regulate the nociceptive transmission through the activation of ER alpha. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | NNSFC[30621062]; MOST[2006CB806600, CASKSCX2-YW-R-31]; [06R214160]; [2007KIP402] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1560]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_感觉系统研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, Xu. Potentiation of excitatory transmission in substantia gelatinosa neurons of rat spinal cord by inhibition of estrogen receptor alpha[J]. MOLECULAR PAIN,2010,6:92-92. |
| APA | Zhang, Xu.(2010).Potentiation of excitatory transmission in substantia gelatinosa neurons of rat spinal cord by inhibition of estrogen receptor alpha.MOLECULAR PAIN,6,92-92. |
| MLA | Zhang, Xu."Potentiation of excitatory transmission in substantia gelatinosa neurons of rat spinal cord by inhibition of estrogen receptor alpha".MOLECULAR PAIN 6(2010):92-92. |
入库方式： OAI收割
来源：上海神经科学研究所
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