Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons
文献类型：期刊论文
| 作者 | Zhang, Xu
|
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2010 |
| 卷号 | 107期号:29页码:13117-13122 |
| 关键词 | dorsal root ganglion spinal cord peptides pain tolerance DORSAL-ROOT GANGLIA RAT SPINAL-CORD AUTORADIOGRAPHIC LOCALIZATION MORPHINE-TOLERANCE MESSENGER-RNAS MICE EXPRESSION ANALGESIA HORN HETERODIMERIZATION |
| ISSN号 | 0027-8424 |
| 通讯作者 | Hokfelt, TGM (reprint author), Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden,tomas.hokfelt@ki.se ; baolan@sibs.ac.cn ; xu.zhang@ion.ac.cn |
| 英文摘要 | Morphine-induced analgesia and antinociceptive tolerance are known to be modulated by interaction between delta-opioid receptors (DORs) and mu-opioid receptors (MORs) in the pain pathway. However, evidence for expression of DORs in nociceptive small-diameter neurons in dorsal root ganglia (DRG) and for coexistence of DORs with MORs and neuropeptides has recently been challenged. We now report, using in situ hybridization, single-cell PCR, and immunostaining, that DORs are widely expressed not only in large DRG neurons but in small ones and coexist with MORs in peptidergic small DRG neurons, with protachykinin-dependent localization in large dense-core vesicles. Importantly, both DOR and MOR agonists reduce depolarization-induced Ca(2+) currents in single small DRG neurons and inhibit afferent C-fiber synaptic transmission in the dorsal spinal cord. Thus, coexistence of DORs and MORs in small DRG neurons is a basis for direct interaction of opioid receptors in modulation of nociceptive afferent transmission and opioid analgesia. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[30621062, 30630029, 30623003]; Ministry of Science and Technology[2006CB806600, 2007CB914501, 2009CB522005]; Chinese Academy of Sciences[KSCX2-YW-R-31, GJHZ06] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1585]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_感觉系统研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, Xu. Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2010,107(29):13117-13122. |
| APA | Zhang, Xu.(2010).Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(29),13117-13122. |
| MLA | Zhang, Xu."Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107.29(2010):13117-13122. |
入库方式： OAI收割
来源：上海神经科学研究所
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