Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons
文献类型：期刊论文
| 作者 | Zhang, Xu
|
| 刊名 | MOLECULAR PAIN
 |
| 出版日期 | 2010 |
| 卷号 | 6页码:23-23 |
| 关键词 | NECROSIS-FACTOR-ALPHA DORSAL-ROOT GANGLION PRIMARY AFFERENT NEURONS CHROMOSOMAL LOCALIZATION NEUROPATHIC PAIN TNF-ALPHA PERIPHERAL INFLAMMATION BOWEL-DISEASE SCIATIC-NERVE GROWTH-FACTOR |
| ISSN号 | 1744-8069 |
| 通讯作者 | Zhang, X (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,xu.zhang@ion.ac.cn |
| 英文摘要 | Pancreatitis-associated protein (PAP)-I and -II, lectin-related secretory proteins, are members of the regenerating gene (Reg) family. Although expression of PAP-I was found in the dorsal root ganglion (DRG) neurons following peripheral nerve injury and cystitis, whether PAP-II could be expressed in DRG neurons in chronic pain models remains unclear. The present study shows an inflammation-and nerve injury-triggered expression of PAP-II in rat DRG neurons. In situ hybridization showed that only a few DRG neurons normally contained PAP-I and -II mRNAs. After peripheral inflammation, PAP-I and -II mRNAs were present in over half of small DRG neurons. Such an elevated expression of PAPI and -II reached the peak level on the second day. Immunostaining showed that the expression of PAP-II was mostly increased in the isolectin B4-positive subset of small DRG neurons after inflammation. Furthermore, the expression of PAP-II was also induced in DRG neurons after peripheral nerve injury. Interestingly, PAP-II expression was shifted from small neurons on day 2 to large DRG neurons that expressed neuropeptide Y during the later post-injury days. These results suggest that PAP-II may play potential roles in the modulation of spinal sensory pathways in pathological pain states. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | NNSFC[30630029, 30621062]; MOST 973 project[2006CB806604, 2009CB522005]; CAS[KSCX1 YW R 31] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1597]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_感觉系统研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, Xu. Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons[J]. MOLECULAR PAIN,2010,6:23-23. |
| APA | Zhang, Xu.(2010).Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons.MOLECULAR PAIN,6,23-23. |
| MLA | Zhang, Xu."Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons".MOLECULAR PAIN 6(2010):23-23. |
入库方式： OAI收割
来源：上海神经科学研究所
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