Regulation of G protein-coupled receptor trafficking
文献类型：期刊论文
| 作者 | Zhang, X.
|
| 刊名 | ACTA PHYSIOLOGICA
 |
| 出版日期 | 2007 |
| 卷号 | 190期号:1页码:39-45 |
| 关键词 | beta-arrestin clathrin constitutive internalization endocytosis export large dense-core vesicle lateral diffusion DELTA-OPIOID-RECEPTOR DORSAL-ROOT GANGLIA KNOCK-OUT MICE SPINAL-CORD ACETYLCHOLINE-RECEPTORS BETA-ARRESTINS CONSTITUTIVE ENDOCYTOSIS PHYSICAL-DEPENDENCE MORPHINE-TOLERANCE DOWN-REGULATION |
| ISSN号 | 1748-1708 |
| 通讯作者 | Xu, ZQD (reprint author), Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden,zhi-qing.xu@ki.se |
| 英文摘要 | G protein-coupled receptors (GPCRs) mediate cellular responses to diverse extracellular stimuli to play a vital role in the control of physiology and behaviour. GPCR trafficking is of fundamental importance for the regulation of GPCRs signaling. In this mini review, we will discuss some of the recent findings on the mechanisms that regulate GPCR trafficking, which include (i) large dense-core vesicle (LDCV)-associated GPCR delivery which could be a general cell biological mechanism for rapid modulation of membrane receptors in response to certain stimuli; (ii) lateral diffusion of GPCRs in the plasma membrane for rapid change of the number of neurotransmitter receptors during synaptic plasticity and (iii) constitutive internalization of GPCRs, that contributes to receptor resensitization and distribution, including axonal polarization. |
| 学科主题 | Physiology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1773]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_感觉系统研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, X.. Regulation of G protein-coupled receptor trafficking[J]. ACTA PHYSIOLOGICA,2007,190(1):39-45. |
| APA | Zhang, X..(2007).Regulation of G protein-coupled receptor trafficking.ACTA PHYSIOLOGICA,190(1),39-45. |
| MLA | Zhang, X.."Regulation of G protein-coupled receptor trafficking".ACTA PHYSIOLOGICA 190.1(2007):39-45. |
入库方式： OAI收割
来源：上海神经科学研究所
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