Differential expression of synaptoporin and synaptophysin in primary sensory neurons and up-regulation of synaptoporin after peripheral nerve injury
文献类型：期刊论文
| 作者 | Zhang, X.
|
| 刊名 | NEUROSCIENCE
 |
| 出版日期 | 2006 |
| 卷号 | 141期号:3页码:1233-1245 |
| 关键词 | synaptic vesicle protein nociceptor dorsal root ganglion dorsal spinal cord sciatic nerve transection gene expression regulation SYNAPTIC VESICLE PROTEIN DORSAL-ROOT GANGLION NEUROPATHIC PAIN MESSENGER-RNA NEUROMUSCULAR SYNAPSES POSTNATAL-DEVELOPMENT HIPPOCAMPAL-NEURONS EXOCYTOTIC RELEASE MEMBRANE-PROTEINS GENE-EXPRESSION |
| ISSN号 | 0306-4522 |
| 通讯作者 | Zhang, X (reprint author), Chinese Acad Sci, Inst Neurosci, Key Lab Neurobiol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,xu.zhang@ion.ac.cn |
| 英文摘要 | Synaptoporin and synaptophysin are integral membrane components of synaptic vesicles. The distribution of synaptoporin and its relationship with synaptophysin in sensory afferent fibers remain unclear. In the present study, we showed that in the rat dorsal root ganglia synaptoporin was expressed in subsets of small neurons that contain either calcitonin gene-related peptide or isolectin B4, and was distributed in their afferent terminals in laminae I-II of the spinal cord. Synaptophysin was expressed in 57% of synaptoporin-containing small dorsal root ganglion neurons and in large dorsal root ganglion neurons. In the spinal dorsal horn, synaptophysin-immunolabeling was weak in the afferent fibers in lamina I, outer lamina II and the dorsal part of inner lamina II, but strong in the afferent fibers in laminae III-IV. However, a subpopulation of isolectin B4-positive small dorsal root ganglion neurons expressed both synaptoporin and synaptophysin, and their afferent fibers were mainly distributed in the ventral part of inner lamina II. After peripheral nerve injury, synaptoporin expression was up-regulated in small dorsal root ganglion neurons, and synaptoporin level was increased in their afferent terminals. Thus, synaptoporin and synaptophysin have topographically distinct distributions in afferent fibers. Synaptoporin is a major synaptic vesicle protein in A delta- and C-fibers in both physiological and neuropathic pain states. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1849]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_感觉系统研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, X.. Differential expression of synaptoporin and synaptophysin in primary sensory neurons and up-regulation of synaptoporin after peripheral nerve injury[J]. NEUROSCIENCE,2006,141(3):1233-1245. |
| APA | Zhang, X..(2006).Differential expression of synaptoporin and synaptophysin in primary sensory neurons and up-regulation of synaptoporin after peripheral nerve injury.NEUROSCIENCE,141(3),1233-1245. |
| MLA | Zhang, X.."Differential expression of synaptoporin and synaptophysin in primary sensory neurons and up-regulation of synaptoporin after peripheral nerve injury".NEUROSCIENCE 141.3(2006):1233-1245. |
入库方式： OAI收割
来源：上海神经科学研究所
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