Gene array analysis to determine the components of neuropathic pain signaling
文献类型：期刊论文
| 作者 | Zhang, X
|
| 刊名 | CURRENT OPINION IN MOLECULAR THERAPEUTICS
 |
| 出版日期 | 2005 |
| 卷号 | 7期号:6页码:532-537 |
| 关键词 | dorsal root ganglion gene expression nerve injury pain spinal cord DORSAL-ROOT GANGLION PERIPHERAL-NERVE INJURY SPINAL-CORD CALCIUM-CHANNEL SENSORY NEURONS SODIUM-CHANNELS RATS AXOTOMY MODEL EXPRESSION |
| ISSN号 | 1464-8431 |
| 通讯作者 | Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Lab Sensory Syst, Shanghai 200031, Peoples R China,xu.zhang@ion.ac.cn |
| 英文摘要 | The molecular modification of the pain pathway represents one of the major mechanisms underlying neuropathic pain. Recently, gene array studies have been carried out to identify the genes that are regulated at the spinal cord level after peripheral nerve injury. These studies demonstrate that peripheral nerve injury causes marked changes in gene expression in both the dorsal root ganglion (DRG) and the dorsal spinal cord. The markedly regulated molecules include, for example, neuropeptides, receptors, ion channels, signal transduction molecules and synaptic vesicle proteins. Upregulation of the Ca2+ channel alpha 2/delta 1 subunit, gamma-aminobutyric acid A receptor alpha 5 subunit, Na+ channels and nicotinic acetylcholine receptors in the DRG and dorsal spinal cord indicates their potential roles in neuropathic pain control. |
| 学科主题 | Biotechnology & Applied Microbiology ; Research & Experimental Medicine |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1860]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_感觉系统研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, X. Gene array analysis to determine the components of neuropathic pain signaling[J]. CURRENT OPINION IN MOLECULAR THERAPEUTICS,2005,7(6):532-537. |
| APA | Zhang, X.(2005).Gene array analysis to determine the components of neuropathic pain signaling.CURRENT OPINION IN MOLECULAR THERAPEUTICS,7(6),532-537. |
| MLA | Zhang, X."Gene array analysis to determine the components of neuropathic pain signaling".CURRENT OPINION IN MOLECULAR THERAPEUTICS 7.6(2005):532-537. |
入库方式： OAI收割
来源：上海神经科学研究所
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