Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion
文献类型：期刊论文
| 作者 | Zhang, X
|
| 刊名 | NEURON
 |
| 出版日期 | 2003 |
| 卷号 | 37期号:1页码:121-133 |
| 关键词 | GENE-RELATED PEPTIDE ADRENAL CHROMAFFIN CELLS CULTURED HIPPOCAMPAL-NEURONS PRIMARY AFFERENT-FIBERS RAT TRIGEMINAL NUCLEUS ROOT GANGLION NEURONS SPINAL-CORD INVIVO SUBSTANCE-P CA2+-DEPENDENT EXOCYTOSIS AMPA RECEPTORS |
| ISSN号 | 0896-6273 |
| 通讯作者 | Zhou, Z (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Lab Sensory Syst, Shanghai, Peoples R China, |
| 英文摘要 | Here we describe a novel mechanism for plasma membrane insertion of the delta opioid receptor (DOR). In small dorsal root ganglion neurons, only low levels of DORs are present on the cell surface, in contrast to high levels of intracellular DORs mainly associated with vesicles containing calcitonin gene-related peptide (CGRP). Activation of surface DORs caused Ca2+ release from lP(3)-sensitive stores and Ca2+ entry, resulting in a slow and long-lasting exocytosis, DOR insertion, and CGRP release. In contrast, membrane depolarization or activation of vanilloid and P2Y, receptors induced a rapid DOR insertion. Thus, DOR activation induces a Ca2+-dependent insertion of DORs that is coupled to a release of excitatory neuropeptides, suggesting that treatment of inflammatory pain should include blockade of DORs. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2029]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_感觉系统研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, X. Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion[J]. NEURON,2003,37(1):121-133. |
| APA | Zhang, X.(2003).Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion.NEURON,37(1),121-133. |
| MLA | Zhang, X."Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion".NEURON 37.1(2003):121-133. |
入库方式： OAI收割
来源：上海神经科学研究所
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