Tools for studying the role of N-cadherin mediated extracellular interaction in neuronal development and function
文献类型：期刊论文
| 作者 | Yu, Xiang |
| 刊名 | CELL ADHESION & MIGRATION
 |
| 出版日期 | 2011 |
| 卷号 | 5期号:3页码:227-231 |
| 关键词 | N-cadherin dendrite development neuronal activity homophilic interaction cell-cell contact activity-independent expression vector CELL-ADHESION MOLECULES HIPPOCAMPAL-NEURONS NEURITE OUTGROWTH FAMILY SYNAPTOGENESIS SPECIFICITY EXPRESSION CATENINS |
| ISSN号 | 1933-6918 |
| 通讯作者 | Yu, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China,yuxiang@ion.ac.cn |
| 英文摘要 | N-cadherin is a homophilic cell adhesion molecule that plays important roles in many aspects of neuronal development. In order to better understand the function of N-cadherin mediated cell-cell contact in activity-dependent dendrite development, we generated a number of new tools. EC1, consisting of the first extracellular domain of N-cadherin, can specifically inhibit N-cadherin, but not E-cadherin, mediated cell-cell contact, both when overexpressed in neurons and added as a purified protein. Ncad-HA is an extracellularly epitope-tagged version of N-cadherin that, when overexpressed under the activity-independent pCS2min promoter, can be used to assay surface N-cadherin level following various manipulations. These tools are likely to be very useful for studying the function of N-cadherin in multiple aspects of neural circuit development. |
| 学科主题 | Cell Biology |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[31021063] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1539]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_树突发育与神经环路形成研究组 |
| 推荐引用方式 GB/T 7714 | Yu, Xiang. Tools for studying the role of N-cadherin mediated extracellular interaction in neuronal development and function[J]. CELL ADHESION & MIGRATION,2011,5(3):227-231. |
| APA | Yu, Xiang.(2011).Tools for studying the role of N-cadherin mediated extracellular interaction in neuronal development and function.CELL ADHESION & MIGRATION,5(3),227-231. |
| MLA | Yu, Xiang."Tools for studying the role of N-cadherin mediated extracellular interaction in neuronal development and function".CELL ADHESION & MIGRATION 5.3(2011):227-231. |
入库方式： OAI收割
来源：上海神经科学研究所
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