N-cadherin-dependent neuron-neuron interaction is required for the maintenance of activity-induced dendrite growth
文献类型：期刊论文
| 作者 | Tan, Zhu-Jun ; Peng, Yun ; Song, He-Ling ; Zheng, Jing-Jing ; Yu, Xiang |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2010 |
| 卷号 | 107期号:21页码:9873-9878 |
| 关键词 | cell adhesion molecule catenin actin CELL-ADHESION BETA-CATENIN HIPPOCAMPAL-NEURONS NEURITE OUTGROWTH SYNAPSE FORMATION ALPHA-CATENIN PLASTICITY COMPLEX SYNAPTOGENESIS MORPHOGENESIS |
| ISSN号 | 0027-8424 |
| 通讯作者 | Yu, XA (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China,yuxiang@ion.ac.cn |
| 英文摘要 | Formation of neural circuits depends on stable contacts between neuronal processes, mediated by interaction of cell adhesion molecules, including N-cadherin. In the present study, we found that activity-dependent dendrite arborization specifically requires N-cadherin-mediated extracellular neuron-neuron interaction, because the enhancement did not occur for neurons cultured in isolation or plated on an astrocyte monolayer and was abolished by a recombinant soluble N-cadherin ectodomain. Furthermore, depolarization elevated the level of membrane-associated cadherin/catenin complexes and surface N-cadherin. Importantly, surface N-cadherin elevationis specifically required for the maintenance of nascent dendrite arbors. Through loss- and gain-of-function approaches, we showed that N-cadherin-mediated dendrite growth requires association of the cadherin/catenin complex with the actin cytoskeleton. In summary, these results identify a previously unexplored and specific function for activity-induced, N-cadherin-mediated neuron-neuron contacts in the maintenance of dendrite arbors. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 资助信息 | Ministry of Science and Technology[2006CB806600, 2006CB943903, 30721004]; National Science Foundation China; Chinese Academy of Sciences[KSCX2-YW-R-103] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1591]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_树突发育与神经环路形成研究组 |
| 推荐引用方式 GB/T 7714 | Tan, Zhu-Jun,Peng, Yun,Song, He-Ling,et al. N-cadherin-dependent neuron-neuron interaction is required for the maintenance of activity-induced dendrite growth[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2010,107(21):9873-9878. |
| APA | Tan, Zhu-Jun,Peng, Yun,Song, He-Ling,Zheng, Jing-Jing,&Yu, Xiang.(2010).N-cadherin-dependent neuron-neuron interaction is required for the maintenance of activity-induced dendrite growth.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(21),9873-9878. |
| MLA | Tan, Zhu-Jun,et al."N-cadherin-dependent neuron-neuron interaction is required for the maintenance of activity-induced dendrite growth".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107.21(2010):9873-9878. |
入库方式： OAI收割
来源：上海神经科学研究所
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