Coordinated Changes in Dendritic Arborization and Synaptic Strength during Neural Circuit Development
文献类型：期刊论文
| 作者 | Peng, Yi-Rong ; He, Shan ; Marie, Helene ; Zeng, Si-Yu ; Ma, Jun ; Tan, Zhu-Jun ; Lee, Soo Yeun ; Malenka, Robert C. ; Yu, Xiang |
| 刊名 | NEURON
 |
| 出版日期 | 2009 |
| 卷号 | 61期号:1页码:71-84 |
| 关键词 | ACTIVITY-DEPENDENT REGULATION LONG-TERM POTENTIATION SILENT SYNAPSES BETA-CATENIN N-CADHERIN GLUTAMATERGIC SYNAPSES HOMEOSTATIC PLASTICITY HIPPOCAMPAL-NEURONS QUANTAL AMPLITUDE VISUAL-CORTEX |
| ISSN号 | 0896-6273 |
| 通讯作者 | Malenka, RC (reprint author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Nancy Pritzker Lab, Palo Alto, CA 94304 USA,malenka@stanford.edu ; yuxiang@ion.ac.cn |
| 英文摘要 | Neural circuit development requires concurrent morphological and functional changes. Here, we identify coordinated and inversely correlated changes in dendritic morphology and mEPSC amplitude following increased neural activity. We show that overexpression of beta-catenin, a molecule that increases total dendritic length, mimics the effects of increased neuronal activity by scaling down mEPSC amplitudes, while postsynaptic expression of a protein that sequesters beta-catenin reverses the effects of activity on reducing mEPSC amplitudes. These results were confirmed immunocytochemically as changes in the size and density of surface synaptic AMPA receptor clusters. In individual neurons there was an inverse linear relationship between total dendritic length and average mEPSC amplitude. Importantly, beta-catenin overexpression in vivo promoted dendritic growth and reduced mEPSC amplitudes. Together, these results demonstrate that coordinated changes in dendritic morphology and unitary excitatory synaptic strength may serve as an important intrinsic mechanism that helps prevent neurons from overexcitation during neural circuit development. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | N.I.M.H.[5 R37 MH063394]; M.O.S.T.[2006CB806600, 2006CB943903]; N.S.F.C.[30721004]; C.A.S[KSCX2-YW-R-103]; Shanghai Municipal Government[06PJ14117] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1683]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_树突发育与神经环路形成研究组 |
| 推荐引用方式 GB/T 7714 | Peng, Yi-Rong,He, Shan,Marie, Helene,et al. Coordinated Changes in Dendritic Arborization and Synaptic Strength during Neural Circuit Development[J]. NEURON,2009,61(1):71-84. |
| APA | Peng, Yi-Rong.,He, Shan.,Marie, Helene.,Zeng, Si-Yu.,Ma, Jun.,...&Yu, Xiang.(2009).Coordinated Changes in Dendritic Arborization and Synaptic Strength during Neural Circuit Development.NEURON,61(1),71-84. |
| MLA | Peng, Yi-Rong,et al."Coordinated Changes in Dendritic Arborization and Synaptic Strength during Neural Circuit Development".NEURON 61.1(2009):71-84. |
入库方式： OAI收割
来源：上海神经科学研究所
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