Serum inducible kinase is a positive regulator of cortical dendrite development and is required for BDNF-promoted dendritic arborization
文献类型：期刊论文
| 作者 | Xiong, Zhi-Qi
|
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2012 |
| 卷号 | 22期号:2页码:387-398 |
| 关键词 | PLK2 morphogenesis BDNF ERK transcription POLO-LIKE KINASES INTEGRIN-BINDING PROTEIN LONG-TERM POTENTIATION BETA-CATENIN SYNAPTIC PLASTICITY HIPPOCAMPAL-NEURONS NEUROTROPHIC FACTOR SIGNALING PATHWAYS ALPHA-SYNUCLEIN NERVOUS-SYSTEM |
| ISSN号 | 1001-0602 |
| 通讯作者 | Xiong, ZQ (reprint author), Chinese Acad Sci, Inst Neurosci, Yueyang Rd 320,ION Bldg,Room 426, Shanghai 200031, Peoples R China,xiongzhiqi@ion.ac.cn |
| 英文摘要 | Serum inducible kinase (SNK), also known as polo-like kinase 2 (PLK2), is a known regulator of mitosis, synaptogenesis and synaptic homeostasis. However, its role in early cortical development is unknown. Herein, we show that snk is expressed in the cortical plate from embryonic day 14, but not in the ventricular/subventricular zones (VZ/SVZ), and SNK protein localizes to the soma and dendrites of cultured immature cortical neurons. Loss of SNK impaired dendritic but not axonal arborization in a dose-dependent manner and overexpression had opposite effects, both in vitro and in vivo. Overexpression of SNK also caused abnormal branching of the leading process of migrating cortical neurons in electroporated cortices. The kinase activity was necessary for these effects. Extracellular signal-regulated kinase (ERK) pathway activity downstream of brain-derived neurotrophic factor (BDNF) stimulation led to increases in SNK protein expression via transcriptional regulation, and this upregulation was necessary for the growth-promoting effect of BDNF on dendritic arborization. Taken together, our results indicate that SNK is essential for dendrite morphogenesis in cortical neurons. |
| 学科主题 | Cell Biology |
| 收录类别 | SCI |
| 资助信息 | 973 Program[2011CBA00407]; NSFC[30925016, 31021063]; Chinese Academy of Sciences[XDA01020305] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1504]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_疾病神经生物学研究组 |
| 推荐引用方式 GB/T 7714 | Xiong, Zhi-Qi. Serum inducible kinase is a positive regulator of cortical dendrite development and is required for BDNF-promoted dendritic arborization[J]. CELL RESEARCH,2012,22(2):387-398. |
| APA | Xiong, Zhi-Qi.(2012).Serum inducible kinase is a positive regulator of cortical dendrite development and is required for BDNF-promoted dendritic arborization.CELL RESEARCH,22(2),387-398. |
| MLA | Xiong, Zhi-Qi."Serum inducible kinase is a positive regulator of cortical dendrite development and is required for BDNF-promoted dendritic arborization".CELL RESEARCH 22.2(2012):387-398. |
入库方式： OAI收割
来源：上海神经科学研究所
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