Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons
文献类型：期刊论文
| 作者 | Xiong, Zhi-Qi
|
| 刊名 | NATURE NEUROSCIENCE
 |
| 出版日期 | 2012 |
| 卷号 | 15期号:2页码:258-266 |
| 关键词 | SCHIZOPHRENIA-LIKE PSYCHOSIS NMDA RECEPTORS KNOCKOUT MICE EPILEPSY RAT BRAIN MODEL HIPPOCAMPUS PLASTICITY SEIZURES |
| ISSN号 | 1097-6256 |
| 通讯作者 | Mei, L (reprint author), Georgias Hlth Sci Univ, Program Dev Neurobiol, Inst Mol Med & Genet, Augusta, GA 30912 USA,lmei@georgiahealth.edu ; xiongzhiqi@ion.ac.cn |
| 英文摘要 | Epilepsy is a common and refractory neurological disorder, but the neuronal regulatory mechanisms of epileptogenesis remain largely unclear. Activity-dependent transcription of genes for neurotrophins such as brain-derived neurotrophic factor (BDNF) has been shown to promote epileptogenesis; however, little is known about factors that may act as intrinsic, homeostatic or counterbalancing mechanisms. Using rodent models, here we show that limbic seizure activity upregulated NRG1-ErbB4 signaling and that epileptogenesis was inhibited by infusing NRG1 intracerebrally but exacerbated by neutralizing endogenous NRG1 with soluble ErbB4 extracellular domain, by inhibiting ErbB4 activation or by deleting the Erbb4 gene. Furthermore, specific depletion of ErbB4 in parvalbumin-expressing interneurons abolished NRG1-mediated inhibition of epileptogenesis and promoted kindling progression, resulting in increased spontaneous seizures and exuberant mossy fiber sprouting. In contrast, depleting ErbB4 in CaMKII alpha-positive pyramidal neurons had no effect. Thus, NRG1-induced activation of ErbB4 in parvalbumin-expressing inhibitory interneurons may serve as a critical endogenous negative-feedback mechanism to suppress limbic epileptogenesis. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | 973 Program[2011CBA00407]; National Natural Science Foundation of China[30925016, 31021063]; Chinese Academy of Sciences[XDA01020305]; US National Institutes of Health |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1506]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_疾病神经生物学研究组 |
| 推荐引用方式 GB/T 7714 | Xiong, Zhi-Qi. Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons[J]. NATURE NEUROSCIENCE,2012,15(2):258-266. |
| APA | Xiong, Zhi-Qi.(2012).Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons.NATURE NEUROSCIENCE,15(2),258-266. |
| MLA | Xiong, Zhi-Qi."Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons".NATURE NEUROSCIENCE 15.2(2012):258-266. |
入库方式： OAI收割
来源：上海神经科学研究所
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