Conditional Deletion of NRSF in Forebrain Neurons Accelerates Epileptogenesis in the Kindling Model
文献类型：期刊论文
| 作者 | Xiong, Zhi-Qi
|
| 刊名 | CEREBRAL CORTEX
 |
| 出版日期 | 2011 |
| 卷号 | 21期号:9页码:2158-2165 |
| ISSN号 | 1047-3211 |
| 关键词 | BDNF epilepsy kainic acid kindling NRSF FIBER SYNAPTIC REORGANIZATION IN-VIVO GENE-EXPRESSION TARGET GENES LIMBIC EPILEPTOGENESIS STATUS EPILEPTICUS REST REPRESSOR TRANSCRIPTION EPILEPSY |
| 通讯作者 | Xiong, ZQ (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,xiongzhiqi@ion.ac.cn |
| 英文摘要 | Neuron-restrictive silencer factor (NRSF), also known as repressor element-1 silencing transcription factor, is a transcriptional repressor that plays important roles in embryonic development and neurogenesis. Recent findings show that NRSF is upregulated after seizures activity however, the link between NRSF and epileptogenesis remains poorly understood. To investigate the role of NRSF in epilepsy, we employed a Cre-loxp system to specifically delete NRSF in excitatory neurons of the postnatal mouse forebrain. In the kindling model of epileptogenesis, conditional NRSF knockout (NRSF-cKO) mice exhibited dramatically accelerated seizure progression and prolonged afterdischarge duration compared with control mice. Moreover, seizures activity-induced mossy fiber sprouting was enhanced in the NRSF-cKO mice. The degree of upregulation of Fibroblast growth factor 14 and Brain-derived neurotrophic factor (BDNF) following kainic acid-induced status epilepticus was significantly increased in the cortex of NRSF-cKO mice compared with control mice. Furthermore, the derepression of BDNF was associated by activation of PLC gamma and PI(3)K signaling pathways. These findings indicate that NRSF functions as an intrinsic repressor of limbic epileptogenesis. |
| 学科主题 | Neurosciences & Neurology |
| 资助信息 | National Basic Research Program of China[2011CBA00407]; The National Natural Science Foundation of China[31021063, 30925016]; SSSTC program[GJHZ0902] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1529]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_疾病神经生物学研究组 |
| 推荐引用方式 GB/T 7714 | Xiong, Zhi-Qi. Conditional Deletion of NRSF in Forebrain Neurons Accelerates Epileptogenesis in the Kindling Model[J]. CEREBRAL CORTEX,2011,21(9):2158-2165. |
| APA | Xiong, Zhi-Qi.(2011).Conditional Deletion of NRSF in Forebrain Neurons Accelerates Epileptogenesis in the Kindling Model.CEREBRAL CORTEX,21(9),2158-2165. |
| MLA | Xiong, Zhi-Qi."Conditional Deletion of NRSF in Forebrain Neurons Accelerates Epileptogenesis in the Kindling Model".CEREBRAL CORTEX 21.9(2011):2158-2165. |
入库方式： OAI收割
来源：上海神经科学研究所
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