Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus
文献类型：期刊论文
| 作者 | Xiong, Zhi-Qi
|
| 刊名 | JOURNAL OF NEUROCHEMISTRY
 |
| 出版日期 | 2009 |
| 卷号 | 111期号:5页码:1094-1103 |
| ISSN号 | 0022-3042 |
| 关键词 | global ischemia hippocampus neurodegeneration proteasome ubiquitination TRANSIENT CEREBRAL-ISCHEMIA PROTEIN AGGREGATION CORTICAL-NEURONS CA1 NEURONS MITOCHONDRIAL DYSFUNCTION DEGRADATION SIGNALS FOREBRAIN ISCHEMIA ZINC TOXICITY INDUCED DEATH NITRIC-OXIDE |
| 通讯作者 | Xiong, ZQ (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,xiongzhiqi@ion.ac.cn |
| 英文摘要 | Deposition of ubiquitinated protein aggregates is a hallmark of neurodegeneration in both acute neural injuries, such as stroke, and chronic conditions, such as Parkinson's disease, but the underlying mechanisms are poorly understood. In the present study, we examined the role of Zn2+ in ischemia-induced impairment of the ubiquitin-proteasome system in the CA1 region of rat hippocampus after transient global ischemia. We found that scavenging endogenous Zn2+ reduced ischemia-induced ubiquitin conjugation and free ubiquitin depletion. Furthermore, exposure to zinc chloride increased ubiquitination and inhibited proteasomal enzyme activity in cultured hippocampal neurons in a concentration- and time-dependent manner. Further studies of the underlying mechanisms showed that Zn2+-induced ubiquitination required p38 activation. These findings indicate that alterations in Zn2+ homeostasis impair the protein degradation pathway. |
| 学科主题 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 资助信息 | National Basic Research Program of China[2006CB806600]; Key State Research Program of China[2006CB943900]; Innovative Research Group of The National Natural Science Foundation of China[30721004]; Chinese Academy of Sciences[KSCX2-YW-R-099] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1627]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_疾病神经生物学研究组 |
| 推荐引用方式 GB/T 7714 | Xiong, Zhi-Qi. Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus[J]. JOURNAL OF NEUROCHEMISTRY,2009,111(5):1094-1103. |
| APA | Xiong, Zhi-Qi.(2009).Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus.JOURNAL OF NEUROCHEMISTRY,111(5),1094-1103. |
| MLA | Xiong, Zhi-Qi."Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus".JOURNAL OF NEUROCHEMISTRY 111.5(2009):1094-1103. |
入库方式： OAI收割
来源：上海神经科学研究所
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