Differential roles of NR2A- and NR2B-containing NMDA receptors in activity-dependent brain-derived neurotrophic factor gene regulation and limbic epileptogenesis
文献类型：期刊论文
| 作者 | Xiong, Zhi-Qi
|
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2007 |
| 卷号 | 27期号:3页码:542-552 |
| 关键词 | epilepsy NR2A NR2B BDNF status epilepticus kindling hippocampus TEMPORAL-LOBE EPILEPSY D-ASPARTATE RECEPTORS FIBER SYNAPTIC REORGANIZATION LONG-TERM POTENTIATION SUBUNIT COMPOSITION STATUS EPILEPTICUS RAT-BRAIN KINDLING DEVELOPMENT CORTICAL-NEURONS CEREBRAL-CORTEX |
| ISSN号 | 0270-6474 |
| 通讯作者 | Xiong, ZQ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,xiongzhiqi@ion.ac.cn |
| 英文摘要 | Fleeting activation of NMDA receptors (NMDARs) induces long-term modification of synaptic connections and refinement of neuronal circuits, which may underlie learning and memory and contribute to pathogenesis of a diversity of neurological diseases, including epilepsy. Here, we found that NR2A and NR2B subunit-containing NMDARs were coupled to distinct intracellular signaling, resulting in differential BDNF expression and extracellular signal-regulated kinase 1/2 (ERK1/2) activation. Selective activation of NR2A-containing NMDARs increased BDNF gene expression. Activation of NR2B-containing NMDARs led to ERK1/2 phosphorylation. Furthermore, selectively blocking NR2A-containing NMDARs impaired epileptogenesis and the development of mossy fiber sprouting in the kindling and pilocarpine rat models of limbic epilepsy, whereas inhibiting NR2B-containing NMDARs had no effects in epileptogenesis and mossy fiber sprouting. Interestingly, blocking either NR2A- or NR2B-containing NMDARs decreased status epilepticus-induced neuronal cell death. The specific requirement of NR2A and its downstream signaling for epileptogenesis implicates attractive new targets for the development of drugs that prevent epilepsy in patients with brain injury. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1791]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_疾病神经生物学研究组 |
| 推荐引用方式 GB/T 7714 | Xiong, Zhi-Qi. Differential roles of NR2A- and NR2B-containing NMDA receptors in activity-dependent brain-derived neurotrophic factor gene regulation and limbic epileptogenesis[J]. JOURNAL OF NEUROSCIENCE,2007,27(3):542-552. |
| APA | Xiong, Zhi-Qi.(2007).Differential roles of NR2A- and NR2B-containing NMDA receptors in activity-dependent brain-derived neurotrophic factor gene regulation and limbic epileptogenesis.JOURNAL OF NEUROSCIENCE,27(3),542-552. |
| MLA | Xiong, Zhi-Qi."Differential roles of NR2A- and NR2B-containing NMDA receptors in activity-dependent brain-derived neurotrophic factor gene regulation and limbic epileptogenesis".JOURNAL OF NEUROSCIENCE 27.3(2007):542-552. |
入库方式： OAI收割
来源：上海神经科学研究所
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