The critical role of CD133(+)CD44(+/high) tumor cells in hematogenous metastasis of liver cancers
文献类型：期刊论文
| 作者 | Wang, Yizheng
|
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2012 |
| 卷号 | 22期号:1页码:259-272 |
| 关键词 | tumor-initiating cells hepatocellular carcinoma metastasis HEPATOCELLULAR-CARCINOMA CELLS STEM-CELLS STEM/PROGENITOR CELLS PLASMINOGEN-ACTIVATOR CLINICAL-SIGNIFICANCE PROGENITOR CELLS EXPRESSION CD44 INVASION CD133 |
| ISSN号 | 1001-0602 |
| 通讯作者 | Wang, YZ (reprint author), Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,shenfengdfgd@yahoo.com.cn ; yzwang@ion.ac.cn |
| 英文摘要 | Metastatic hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide. However, the cell population responsible for its metastasis remains largely unknown. Here, we reported that CD133(+) CD44(+/high) defined a subgroup of tumor cells that was responsible for hematogenous metastasis of liver cancers. Immunohistochemical investigation of human HCC specimens revealed that the number of CD133(+) and CD44(+) HCC cells was increased and was associated with portal vein invasion. Purified CD133(+) or CD44(high) HCC cells were superior in clonogenic growth and vascular invasion, respectively. Thus, the combination of CD133 and CD44 was used to define a novel HCC sub-population. CD133(+) CD44(high), but not CD133(+) CD44(low/-), CD133-CD44(high) or CD133-CD44(low/-) xenografts, produced intrahepatic or lung metastasis in nude mice. Further analysis of human HCC samples by flow cytometry showed that the number of CD133(+) CD44(+) tumor cells was associated with portal vein metastasis. The cDNA microarray analysis of CD133(+) CD44(+) and CD133(+) CD44-tumor cells isolated from metastatic HCC patients revealed that these cells comprised of two different populations possessing distinct gene expression profiles. Our results suggest that CD133(+) CD44(+) tumor cells are a particular population responsible for hematogenous metastasis in liver cancers and that these cells might be targets for treatment of HCC metastasis. |
| 学科主题 | Cell Biology |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Program of China[2011CBA00400]; State Key Project for Research of Infectious Diseases[2008zx10002-025]; National Natural Science Foundation of China[30711120566] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1513]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经信号转导研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Yizheng. The critical role of CD133(+)CD44(+/high) tumor cells in hematogenous metastasis of liver cancers[J]. CELL RESEARCH,2012,22(1):259-272. |
| APA | Wang, Yizheng.(2012).The critical role of CD133(+)CD44(+/high) tumor cells in hematogenous metastasis of liver cancers.CELL RESEARCH,22(1),259-272. |
| MLA | Wang, Yizheng."The critical role of CD133(+)CD44(+/high) tumor cells in hematogenous metastasis of liver cancers".CELL RESEARCH 22.1(2012):259-272. |
入库方式： OAI收割
来源：上海神经科学研究所
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