Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells
文献类型：期刊论文
| 作者 | Wang, Yizheng
|
| 刊名 | INTERNATIONAL JOURNAL OF CANCER
 |
| 出版日期 | 2009 |
| 卷号 | 125期号:10页码:2281-2287 |
| 关键词 | TRPC6 gastric cancer cell cycle RECEPTOR POTENTIAL CHANNELS PROLIFERATION CA2+ CHECKPOINTS ACTIVATION EXPRESSION ENTRY |
| ISSN号 | 0020-7136 |
| 通讯作者 | Wang, YZ (reprint author), Chinese Acad Sci, Inst Neurosci, SIBS, Lab Neural Signal Transduct, 320 Yueyang Rd, Shanghai 200031, Peoples R China, |
| 英文摘要 | Channels formed by file canonical transient receptor potential (TRPC) subfamily of proteins are Ca(2+)-permeable, nonselective cation channels with various functions. Through I phospholipase C (PLO-dependent mechanism TRPC6, a member of TRPC subfamily. can be activated by receptor tyrosine kinases (RTK) or G protein-coupled receptors (GPCR),. which are implicated in cell proliferation and human malignancies. Here, we report that TRPC6 has a critical role in human gastric cancer development. Expression of TRPC6 Was greatly upregulated in human gastric cancer epithelial cells compared with that in normal gastric epithelial cells. Treatment of AGS or MKN45 cells, human gastric cancer cell lines, with SKF96365, an agent known to inhibit TRPC channels. arrested cell cycle in G2/M phase and suppressed cell growth. Importantly, expressing a dominant negative mutant of TRPC6 (DNC6) in these cells also arrested cell cycle in G2/M phase all inhibited cell growth. The Ca(2+) elevation in the MKN45 cells evoked by histamine war, inhibited by SKF96365 and DNC6. Moreover, inhibition of TRPC6 suppressed the formation of gastric tumors in nude mice. These results suggest that Ca(2+) elevation regulated by TRPC6 channels is essential for G2/M phase transition and for the development of gastric cancers. (C) 2009 UICC |
| 学科主题 | Oncology |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[200603806600] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1629]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经信号转导研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Yizheng. Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells[J]. INTERNATIONAL JOURNAL OF CANCER,2009,125(10):2281-2287. |
| APA | Wang, Yizheng.(2009).Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells.INTERNATIONAL JOURNAL OF CANCER,125(10),2281-2287. |
| MLA | Wang, Yizheng."Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells".INTERNATIONAL JOURNAL OF CANCER 125.10(2009):2281-2287. |
入库方式： OAI收割
来源：上海神经科学研究所
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