Critical role of TRPC6 channels in VEGF-mediated angiogenesis
文献类型：期刊论文
| 作者 | Wang, Yizheng
|
| 刊名 | CANCER LETTERS
 |
| 出版日期 | 2009 |
| 卷号 | 283期号:1页码:43-51 |
| 关键词 | TRPC6 Angiogenesis VEGF Proliferation Tube formation ENDOTHELIAL GROWTH-FACTOR VASCULAR-PERMEABILITY FACTOR RECEPTOR POTENTIAL CHANNELS CELL LUNG-CANCER CATION CHANNEL TUMOR ANGIOGENESIS PLUS CARBOPLATIN EPITHELIAL-CELLS CA2+ ENTRY IN-VIVO |
| ISSN号 | 0304-3835 |
| 通讯作者 | Shen, F (reprint author), Mil Med Coll 2, Div Comprehens Treatment, Eastern Hepatobiliary Hosp, Shanghai 200438, Peoples R China,shenfengdfgd@yahoo.com.cn ; yzwang@ion.ac.cn |
| 英文摘要 | Intracellular Ca(2+) signaling plays critical roles in VEGF-mediated angiogenesis. Transient receptor potential canonical (TRPC) channel 6, a Ca(2+)-permeable non-selective cation channel, can be activated by VEGF. Here, we report that TRPC6 is important for VEGF-mediated angiogenesis. Inhibition of TRPC6 in human umbilical vein endothelial cells (HUVECs) by pharmacological or genetic approaches arrested HUVECs at G2/M phase and suppressed VEGF-induced HUVEC proliferation and tube formation. Furthermore, inhibition of TRPCs abolished VEGF-, but not FGF-induced angiogenesis in the chick embryo chorioallantoic membrane. These results suggest that TRPC6 plays an important role in VEGF-mediated angiogenesis. (C) 2009 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Oncology |
| 收录类别 | SCI |
| 资助信息 | Shanghai Municipal Council for Science and Technology[064119530]; 973 Program[2006CB806600]; National Natural Science Foundation of China[30872989, 30621062] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1640]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经信号转导研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Yizheng. Critical role of TRPC6 channels in VEGF-mediated angiogenesis[J]. CANCER LETTERS,2009,283(1):43-51. |
| APA | Wang, Yizheng.(2009).Critical role of TRPC6 channels in VEGF-mediated angiogenesis.CANCER LETTERS,283(1),43-51. |
| MLA | Wang, Yizheng."Critical role of TRPC6 channels in VEGF-mediated angiogenesis".CANCER LETTERS 283.1(2009):43-51. |
入库方式： OAI收割
来源：上海神经科学研究所
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