The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity
文献类型：期刊论文
| 作者 | Wang, Yizheng ; Yao, Hailan
|
| 刊名 | JOURNAL OF NEUROCHEMISTRY
 |
| 出版日期 | 2009 |
| 卷号 | 108期号:4页码:909-919 |
| 关键词 | apoptosis cortical neuron Kv2 1 membrane trafficking NMDA CELL-SURFACE MICRODOMAINS METHYL-D-ASPARTATE POTASSIUM CHANNEL K+ CHANNEL DEPENDENT TRAFFICKING SYNAPTIC PLASTICITY CORTICAL-NEURONS PROTEIN-KINASE PHOSPHORYLATION HIPPOCAMPAL |
| ISSN号 | 0022-3042 |
| 通讯作者 | Wang, YZ (reprint author), Inst Neurosci, SIBS, State Key Lab Neurosci, Lab Neural Signal Transduct, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn |
| 英文摘要 | Chronic loss of intracellular K(+) can induce neuronal apoptosis in pathological conditions. However, the mechanism by which the K(+) channels are regulated in this process remains largely unknown. Here, we report that the increased membrane expression of Kv2.1 proteins in cortical neurons deprived of serum, a condition known to induce K(+) loss, promotes neuronal apoptosis. The increase in I(K) current density and apoptosis in the neurons deprived of serum were inhibited by a dominant negative form of Kv2.1 and MK801, an antagonist to NMDA receptors. The membrane level of Kv2.1 and its interaction with SNAP25 were increased, whereas the Kv2.1 phosphorylation was inhibited in the neurons deprived of serum. Botulinum neurotoxin, an agent known to prevent formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex, suppressed the increase in I(K) current density. Together, these results suggest that NMDA receptor-dependent Kv2.1 membrane translocation is regulated by a soluble N-ethylmaleimide-sensitive factor attachment protein receptor-dependent vesicular trafficking mechanism and is responsible for neuronal cell death induced by chronic loss of K(+). |
| 学科主题 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | NNSF of China[KSCX2-YW-R-099, 2006CB806600, 30621062, 30711120566, U0632006] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1680]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经信号转导研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Yizheng,Yao, Hailan. The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity[J]. JOURNAL OF NEUROCHEMISTRY,2009,108(4):909-919. |
| APA | Wang, Yizheng,&Yao, Hailan.(2009).The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity.JOURNAL OF NEUROCHEMISTRY,108(4),909-919. |
| MLA | Wang, Yizheng,et al."The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity".JOURNAL OF NEUROCHEMISTRY 108.4(2009):909-919. |
入库方式： OAI收割
来源：上海神经科学研究所
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