ZNF23 induces apoptosis in human ovarian cancer cells
文献类型：期刊论文
| 作者 | Wang, Yizheng
|
| 刊名 | CANCER LETTERS
 |
| 出版日期 | 2008 |
| 卷号 | 266期号:2页码:135-143 |
| 关键词 | ZNF23 Bcl-X-L apoptosis CASPASE ACTIVATION IN-VITRO BCL-X INHIBITOR PROTEIN DEATH PROLIFERATION CYCLE |
| ISSN号 | 0304-3835 |
| 通讯作者 | Shen, F (reprint author), Mil Med Coll 2, Eastern Hepalobiliary Surg Hosp, Div Comprehens Treatment, Shanghai 200438, Peoples R China,shenfengdfgd@yahoo.com.cn ; yzwang@ion.ac.cn |
| 英文摘要 | We recently reported that the level of ZNF23, a KRAB-containing zinc finger protein, is reduced in human cancers and it inhibits cell growth by inducing Cell Cycle arrest. Here we showed that ZNF23 also induces apoptosis in ovarian cancer cells. The protein level of ZNF23 in ovarian cancers was greatly down-regulated compared with that in the normal ovaries. Introduction of ZNF23 into ovarian cancer cells led to apoptosis as demonstrated by activation of caspase-3, nuclear condensation and formation of a sub-G1 peak. This apoptotic process was correlated with loss in mitochondrial membrane potential, cytochrome c release and caspase-9 activation. Furthermore, ZNF23 induced apoptosis partially via down-regulation of Bcl-X-L, Thus, our results suggest that ZNF23 may also induce apoptosis to suppress tumor cell growth and points to the possibility that its down-regulation might facilitate ovarian cancer cell survival. (C) 2008 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Oncology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1704]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经信号转导研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Yizheng. ZNF23 induces apoptosis in human ovarian cancer cells[J]. CANCER LETTERS,2008,266(2):135-143. |
| APA | Wang, Yizheng.(2008).ZNF23 induces apoptosis in human ovarian cancer cells.CANCER LETTERS,266(2),135-143. |
| MLA | Wang, Yizheng."ZNF23 induces apoptosis in human ovarian cancer cells".CANCER LETTERS 266.2(2008):135-143. |
入库方式： OAI收割
来源：上海神经科学研究所
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