TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway
文献类型：期刊论文
| 作者 | Wang, Yizheng
|
| 刊名 | JOURNAL OF CELL SCIENCE
 |
| 出版日期 | 2008 |
| 卷号 | 121期号:14页码:2301-2307 |
| 关键词 | TRPC channels dendritic development Ca(2+)/calmodulin-dependent kinase IV (CaMKIV) CREB RAT SUBSTANTIA-NIGRA PROTEIN-KINASE-IV MEDIATED TRANSCRIPTION CELLULAR-LOCALIZATION NEUROTROPHIC FACTOR TRANSIENT RECEPTOR BINDING PROTEIN CALCIUM ACTIVATION BRAIN |
| ISSN号 | 0021-9533 |
| 通讯作者 | Wang, YZ (reprint author), Chinese Acad Sci, Lab Neural Signal Transduct, Inst Neurosci,Grad Sch, Shanghai Inst Biol Sci,State Key Lab Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn |
| 英文摘要 | The canonical transient receptor potential channels (TRPCs) are Ca(2+)-permeable nonselective cation channels with various physiological functions. Here, we report that TRPC6, a member of the TRPC family, promotes hippocampal neuron dendritic growth. The peak expression of TRPC6 in rat hippocampus was between postnatal day 7 and 14, a period known to be important for maximal dendritic growth. Overexpression of TRPC6 increased phosphorylation of Ca(2+)/calmodulin-dependent kinase IV (CaMKIV) and cAMP-response-element binding protein (CREB) and promoted dendritic growth in hippocampal cultures. Downregulation of TRPC6 by short hairpin RNA interference against TRPC6 suppressed phosphorylation of both CaMKIV and CREB and impaired dendritic growth. Expressing a dominant-negative form of CaMKIV or CREB blocked the TRPC6-induced dendritic growth. Furthermore, inhibition of Ca(2+) influx suppressed the TRPC6 effect on dendritic growth. Finally, in TRPC6 transgenic mice, the phosphorylation of CaMKIV and CREB was enhanced and the dendritic growth was also increased. In conclusion, TRPC6 promoted dendritic growth via the CaMKIV-CREB pathway. Our results thus revealed a novel role of TRPC6 during the development of the central nervous system (CNS). |
| 学科主题 | Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1715]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经信号转导研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Yizheng. TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway[J]. JOURNAL OF CELL SCIENCE,2008,121(14):2301-2307. |
| APA | Wang, Yizheng.(2008).TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway.JOURNAL OF CELL SCIENCE,121(14),2301-2307. |
| MLA | Wang, Yizheng."TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway".JOURNAL OF CELL SCIENCE 121.14(2008):2301-2307. |
入库方式： OAI收割
来源：上海神经科学研究所
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