The Kv4.2 mediates excitatory activity-dependent regulation of neuronal excitability in rat cortical neurons
文献类型：期刊论文
| 作者 | Wang, Yizheng
|
| 刊名 | JOURNAL OF NEUROCHEMISTRY
 |
| 出版日期 | 2008 |
| 卷号 | 105期号:3页码:773-783 |
| 关键词 | excitability glutamate Kv4.2 NMDA receptor translocation ACTIVATED PROTEIN-KINASE LONG-TERM POTENTIATION INTRINSIC EXCITABILITY PYRAMIDAL NEURONS SYNAPTIC PLASTICITY K+ CHANNELS DENDRITIC EXCITABILITY HOMEOSTATIC PLASTICITY POTASSIUM CURRENTS LTP INDUCTION |
| ISSN号 | 0022-3042 |
| 通讯作者 | Shen, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Key Lab Neurobiol,Grad Sch, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn |
| 英文摘要 | Neuronal excitability can cooperate with synaptic transmission to control the information storage. This regulation of neuronal plasticity can be affected by alterations in neuronal inputs and accomplished by modulation of voltage-dependent ion channels. In this study, we report that enhanced excitatory input negatively regulated neuronal excitability. Enhanced excitatory input by glutamate, electric field stimulation or high K+ increased transient outward K+ current, whereas did not affect the delayed rectifier K+ current in rat cultured cortical neurons. Both the voltage-dependent K+ channel 4.2 and 4.3 subunits contributed to the increase. The increase in the K+ current density by Kv4.2 was ascribed to its cytoplasmic membrane translocation, which was mediated by NMDA type of glutamate receptor. Furthermore, enhanced excitatory input inhibited neuronal excitability. Taken together, our results suggest that excitatory neurotransmission affects neuronal excitability via the regulation of the K+ channel membrane translocation. |
| 学科主题 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1732]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经信号转导研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Yizheng. The Kv4.2 mediates excitatory activity-dependent regulation of neuronal excitability in rat cortical neurons[J]. JOURNAL OF NEUROCHEMISTRY,2008,105(3):773-783. |
| APA | Wang, Yizheng.(2008).The Kv4.2 mediates excitatory activity-dependent regulation of neuronal excitability in rat cortical neurons.JOURNAL OF NEUROCHEMISTRY,105(3),773-783. |
| MLA | Wang, Yizheng."The Kv4.2 mediates excitatory activity-dependent regulation of neuronal excitability in rat cortical neurons".JOURNAL OF NEUROCHEMISTRY 105.3(2008):773-783. |
入库方式： OAI收割
来源：上海神经科学研究所
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