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Inhibition of glycogen synthase kinase-3 beta protects doparninergic neurons from MPTP toxicity
文献类型：期刊论文
| 作者 | Wang, Yizheng
|
| 刊名 | NEUROPHARMACOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 52期号:8页码:1678-1684 |
| ISSN号 | 0028-3908 |
| 关键词 | GSK-3 beta indirubin-3'-oxime AR-A014418 dopaminergic neurons MPTP Parkinson's disease PARKINSONS-DISEASE DOPAMINERGIC-NEURONS ALZHEIMERS-DISEASE KINASE 3-BETA TAU-PROTEIN SWIM-TEST MOUSE PHOSPHORYLATION MODEL MICE |
| 通讯作者 | Li, MT (reprint author), Sun Yat Sen Univ, Zhong Sch Med, Inst Clin Pharmacol, Guangzhou 510515, Guangdong, Peoples R China,limt@mail.sysu.edu.cn |
| 英文摘要 | Glycogen synthase kinase-3 beta (GSK-3 beta) is closely involved in neuronal apoptosis and pathogenesis of many neurodegenerative diseases, such as Alzheimer's disease. However, whether GSK-3 beta mediates apoptosis of dopaminergic neurons in Parkinson's disease remains elusive. In this study, using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism models, we investigated whether MPTP induces apoptosis of dopaminergic neurons through a GSK-3 beta-dependent pathway. MPTP caused a rapid activation of GSK-3 beta, evidenced by the decrease in level of phospho-Ser9 of GSK-3 beta and the increase in level of phospho-Ser396 of tau, a known GSK-3 beta substrate. Blockage of GSK-3 beta activity by its two specific inhibitors, indirubin-3'-oxime and AR-A014418, prevented dopaminergic neurons from MPTP-induced apoptosis. Additionally, inhibition of GSK-3 beta activity restored the depletion of striatal dopamine and ameliorated behavioral impairments caused by MPTP. These results indicate that GSK-3 beta is a critical intermediate of MPTP neurotoxicity, and inhibition of GSK-3 beta may provide a novel strategy to treat Parkinson's disease. (c) 2007 Elsevier Ltd. All rights reserved. |
| 学科主题 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1770]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经信号转导研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Yizheng. Inhibition of glycogen synthase kinase-3 beta protects doparninergic neurons from MPTP toxicity[J]. NEUROPHARMACOLOGY,2007,52(8):1678-1684. |
| APA | Wang, Yizheng.(2007).Inhibition of glycogen synthase kinase-3 beta protects doparninergic neurons from MPTP toxicity.NEUROPHARMACOLOGY,52(8),1678-1684. |
| MLA | Wang, Yizheng."Inhibition of glycogen synthase kinase-3 beta protects doparninergic neurons from MPTP toxicity".NEUROPHARMACOLOGY 52.8(2007):1678-1684. |
入库方式： OAI收割
来源：上海神经科学研究所
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