Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression
文献类型：期刊论文
| 作者 | Wang, Yizheng
|
| 刊名 | EXPERIMENTAL CELL RESEARCH
 |
| 出版日期 | 2007 |
| 卷号 | 313期号:2页码:254-263 |
| 关键词 | ZNF23 KRAB cell cycle G(1) phase p27(kip-1) p53 ZINC-FINGER PROTEINS TRANSCRIPTIONAL REPRESSION CHROMOSOME 16Q22 DOMAIN COREPRESSOR GROWTH GENES ZBRK1 SUPPRESSION EXPRESSION |
| ISSN号 | 0014-4827 |
| 通讯作者 | Wang, YZ (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn |
| 英文摘要 | The Krupple-associated box-containing zinc-finger proteins (KRAB-ZFPs) make up one of the largest family of transcription factors. Several members of the KRAB-ZFPs modulate cell growth, survival and are implicated in malignant disorders. However, most members are not well characterized and their functions are largely unknown. Here we report that ZNF23, a member of KRAB-ZFPs, inhibits cell cycle progression. ZNF23 protein localized to the nucleus and was ubiquitously expressed in all tested normal tissues. However, the expression levels of ZNF23 protein were lost or greatly reduced in human cancer. Ectopic expression of ZNF23 led to enhancement of p27(kip-1) expression, growth inhibition and cell cycle arrest in G(1) phase. Downregulation of p27(kip-1) by siRNA against p27(kip-1) reversed growth inhibition induced by ZNF23. Furthermore, the growth-inhibitory effect of ZNF23 was p53-independent. Deletion analysis revealed that the effect of ZNF23 did not rely on its KRAB domain, but on the C-terminal zinc fingers. Thus, we have identified a new member of KRAB-ZNF superfamily with growth-inhibitory ability and its downregulation may contribute to carcinogenesis. (c) 2006 Elsevier Inc. All rights reserved. |
| 学科主题 | Oncology ; Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1793]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经信号转导研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Yizheng. Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression[J]. EXPERIMENTAL CELL RESEARCH,2007,313(2):254-263. |
| APA | Wang, Yizheng.(2007).Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression.EXPERIMENTAL CELL RESEARCH,313(2),254-263. |
| MLA | Wang, Yizheng."Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression".EXPERIMENTAL CELL RESEARCH 313.2(2007):254-263. |
入库方式： OAI收割
来源：上海神经科学研究所
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