Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity
文献类型：期刊论文
| 作者 | Wang, Yizheng
|
| 刊名 | JOURNAL OF CELL BIOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 174期号:3页码:415-424 |
| 关键词 | AKT/PROTEIN KINASE-B HIPPOCAMPAL-NEURONS PROTEIN-DEGRADATION NEURITE OUTGROWTH PI 3-KINASE CELLS GROWTH ESTABLISHMENT INHIBITION GSK-3-BETA |
| ISSN号 | 0021-9525 |
| 通讯作者 | Wang, YZ (reprint author), Chinese Acad Sci, Lab Neural Signal Transduct, Inst Neurosci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn |
| 英文摘要 | A symmetric distributions of activities of the protein kinases Akt and glycogen synthase kinase 3 beta (GSK-3 beta) are critical for the formation of neuronal polarity. However, the mechanisms underlying polarized regulation of this pathway remain unclear. In this study, we report that the instability of Akt regulated by the ubiquitin - proteasome system ( UPS) is required for neuron polarity. Preferential distribution in the axons was observed for Akt but not for its target GSK-3 beta. A photoactivatable GFP fused to Akt revealed the preferential instability of Akt in dendrites. Akt but not p110 or GSK-3 beta was ubiquitinated. Suppressing the UPS led to the symmetric distribution of Akt and the formation of multiple axons. These results indicate that local protein degradation mediated by the UPS is important in determining neuronal polarity. |
| 学科主题 | Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1809]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经信号转导研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Yizheng. Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity[J]. JOURNAL OF CELL BIOLOGY,2006,174(3):415-424. |
| APA | Wang, Yizheng.(2006).Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity.JOURNAL OF CELL BIOLOGY,174(3),415-424. |
| MLA | Wang, Yizheng."Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity".JOURNAL OF CELL BIOLOGY 174.3(2006):415-424. |
入库方式： OAI收割
来源：上海神经科学研究所
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