Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques
文献类型：期刊论文
| 作者 | Qiu, Zilong
|
| 刊名 | GENOME RESEARCH
 |
| 出版日期 | 2012 |
| 卷号 | 22期号:4页码:611-622 |
| 关键词 | HUMAN PREFRONTAL CORTEX NONHUMAN PRIMATE BRAINS LONG-TERM POTENTIATION CENTRAL-NERVOUS-SYSTEM HUMAN LIFE-HISTORY GENE-EXPRESSION TRANSCRIPTION FACTOR POSTSYNAPTIC DENSITY MAMMALIAN BRAINS CEREBRAL-CORTEX |
| ISSN号 | 1088-9051 |
| 通讯作者 | Qiu, ZL (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China,zqlu@ion.ac.cn ; paabo@eva.mpg.de ; khaltovich@eva.mpg.de |
| 英文摘要 | Over the course of ontogenesis, the human brain and human cognitive abilities develop in parallel, resulting in a phenotype strikingly distinct from that of other primates. Here, we used microarrays and RNA-sequencing to examine human-specific gene expression changes taking place during postnatal brain development in the prefrontal cortex and cerebellum of humans, chimpanzees, and rhesus macaques. We show that the most prominent human-specific expression change affects genes associated with synaptic functions and represents an extreme shift in the timing of synaptic development in the prefrontal cortex, but not the cerebellum. Consequently, peak expression of synaptic genes in the prefrontal cortex is shifted from <1 yr in chimpanzees and macaques to 5 yr in humans. This result was supported by protein expression profiles of synaptic density markers and by direct observation of synaptic density by electron microscopy. Mechanistically, the human-specific change in timing of synaptic development involves the MEF2A-mediated activity-dependent regulatory pathway. Evolutionarily, this change may have taken place after the split of the human and the Neanderthal lineages. |
| 学科主题 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 收录类别 | SCI |
| 资助信息 | Ministry of Science and Technology of the People's Republic of China[2007CB947004]; Chinese Academy of Sciences[KSCX2-YW-R-094, KSCX2-YWR-251, 2009Y2BS12]; Shanghai Institutes for Biological Sciences[2008KIT104]; National Science Foundation of China[31010022, 31050110128]; 973 program[2011CBA00400]; Max Planck-Society; Bundesministerum fuer Bildung und Forschung; European Molecular Biology Organization (EMBO)[ALTF 1475-2010] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1494]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性分子基础研究组 |
| 推荐引用方式 GB/T 7714 | Qiu, Zilong. Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques[J]. GENOME RESEARCH,2012,22(4):611-622. |
| APA | Qiu, Zilong.(2012).Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques.GENOME RESEARCH,22(4),611-622. |
| MLA | Qiu, Zilong."Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques".GENOME RESEARCH 22.4(2012):611-622. |
入库方式： OAI收割
来源：上海神经科学研究所
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