The Rett Syndrome Protein MeCP2 Regulates Synaptic Scaling
文献类型：期刊论文
| 作者 | Qiu, Zilong
|
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2012 |
| 卷号 | 32期号:3页码:989-994 |
| 关键词 | CPG-BINDING PROTEIN-2 AMPA RECEPTOR HIPPOCAMPAL-NEURONS SUBUNIT EXPRESSION EXCITATION SYNAPSES GENE |
| ISSN号 | 0270-6474 |
| 通讯作者 | Ghosh, A (reprint author), Univ Calif San Diego, Div Biol Sci, Neurobiol Sect, La Jolla, CA 92093 USA,aghosh@ucsd.edu |
| 英文摘要 | Synaptic scaling is a form of homeostatic synaptic plasticity characterized by cell-wide changes in synaptic strength in response to changes in overall levels of neuronal activity. Here we report that bicuculline-induced increase in neuronal activity leads to a decrease in mEPSC amplitude and a decrease in expression of the AMPA receptor subunit GluR2 in rat hippocampal cultures. Bicuculline treatment also leads to an increase in the levels of the transcriptional repressor MeCP2, which binds to the GluR2 promoter along with the corepressors HDAC1 and mSin3A. Downregulation of MeCP2 by shRNA expression or genetic deletion blocks the bicuculline-induced decrease in GluR2 expression and mEPSC amplitude. These observations indicate that MeCP2 mediates activity-dependent synaptic scaling, and suggest that the pathophysiology of Rett syndrome, which is caused by mutations in MeCP2, may involve defects in activity-dependent regulation of synaptic currents. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | NIH[MH068578]; Rett Syndrome Research Foundation/International Rett Syndrome Foundation; Chinese Academy of Sciences, China |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1509]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性分子基础研究组 |
| 推荐引用方式 GB/T 7714 | Qiu, Zilong. The Rett Syndrome Protein MeCP2 Regulates Synaptic Scaling[J]. JOURNAL OF NEUROSCIENCE,2012,32(3):989-994. |
| APA | Qiu, Zilong.(2012).The Rett Syndrome Protein MeCP2 Regulates Synaptic Scaling.JOURNAL OF NEUROSCIENCE,32(3),989-994. |
| MLA | Qiu, Zilong."The Rett Syndrome Protein MeCP2 Regulates Synaptic Scaling".JOURNAL OF NEUROSCIENCE 32.3(2012):989-994. |
入库方式： OAI收割
来源：上海神经科学研究所
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