The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond
文献类型：期刊论文
| 作者 | Qiu, Zilong
|
| 刊名 | NEUROSIGNALS
 |
| 出版日期 | 2010 |
| 卷号 | 18期号:2页码:72-81 |
| 关键词 | Calcium Transcription MeCP2 Copy number variations SPINOCEREBELLAR ATAXIA TYPE-1 UBIQUITIN-PROTEIN LIGASE COPY NUMBER VARIATION RETT-SYNDROME MOUSE MODEL ANGELMAN-SYNDROME TRANSCRIPTIONAL REPRESSION INTERSTITIAL DELETION SYNAPTIC-TRANSMISSION NEUROLOGICAL DISEASE |
| ISSN号 | 1424-862X |
| 通讯作者 | Qiu, ZL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Yueyang Rd 320, Shanghai 200031, Peoples R China,zqiu@ion.ac.cn |
| 英文摘要 | During the last decade, autism spectrum disorders (ASD) have become the center of attention where several branches of modern biology unexpectedly meet, such as neural development, molecular biology, epigenetics, neurophysiology and psychiatry. This review will focus on the molecular mechanism by which calcium-dependent gene expression regulates brain development and how ASD may occur if this process is compromised. Specifically, the studies of the calcium-dependent transcriptional repressor MeCP2 gave us much insight about how abnormal development may lead to ASD. Most recently, studies about Ube3a, a critical component of the ubiquitination system enzyme, shed light on how neural activity regulates synapse function through the protein degradation pathway. Taken together, these studies suggest that ASD may be caused by the incapability of neurons to generate adaptive responses via regulating gene expression upon incoming activity. Copyright (C) 2010 S. Karger AG, Basel |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology ; Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | Hundreds of Talents Program; Chinese Academy of Sciences |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1622]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性分子基础研究组 |
| 推荐引用方式 GB/T 7714 | Qiu, Zilong. The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond[J]. NEUROSIGNALS,2010,18(2):72-81. |
| APA | Qiu, Zilong.(2010).The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond.NEUROSIGNALS,18(2),72-81. |
| MLA | Qiu, Zilong."The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond".NEUROSIGNALS 18.2(2010):72-81. |
入库方式： OAI收割
来源：上海神经科学研究所
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