Postinduction Requirement of NMDA Receptor Activation for Late-Phase Long-Term Potentiation of Developing Retinotectal Synapses In Vivo
文献类型：期刊论文
| 作者 | Poo, Mu-ming
|
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2011 |
| 卷号 | 31期号:9页码:3328-3335 |
| 关键词 | AMPA RECEPTORS SYNAPTIC PLASTICITY PROTEIN-SYNTHESIS MEMORY STORAGE OPTIC TECTUM MOLECULAR-BIOLOGY CRITICAL PERIOD LTP APLYSIA HIPPOCAMPUS |
| ISSN号 | 0270-6474 |
| 通讯作者 | Poo, MM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,mpoo@berkeley.edu ; xhzhang@ion.ac.cn |
| 英文摘要 | Spaced patterns of repetitive synaptic activation often result in a long-lasting, protein synthesis-dependent potentiation of synaptic transmission, known as late-phase long-term potentiation (L-LTP) that may serve as a substrate for long-term memory. Behavioral studies showed that posttraining blockade of NMDA subtype of the glutamate receptor (NMDAR) impaired long-term memory, although NMDAR activation is generally known to be required during LIP induction. In this study, we found that the establishment of L-LIP in vivo requires NMDAR activation within a critical time window after LIP induction. In the developing visual system of Xenopus laevis tadpole, L-LIP of retinotectal synapses could be induced by three episodes of theta burst stimulation (IBS) of the optic nerve with 5 min spacing ("spaced IBS"), but not by three TBS episodes applied en masse or spaced with intervals >= 10 min. Within a time window of similar to 30 min after the spaced TBS, local perfusion of the tectum with NMDAR antagonist D-AP5 or Ca(2+)-chelator EGTA-AM impaired the establishment of L-LTP, indicating the requirement of postinduction activation of NMDAR/Ca(2+) signaling. Moreover, inhibiting spontaneous spiking activity in the tectum by local application of tetrodotoxin (TTX) prevented L-LIP when TTX was applied for 15 min immediately after the spaced TBS but not I h later, whereas the same postinduction TTX application in the retina had no effect. These findings offer new insights into the synaptic basis for the requirement of postlearning activation of NMDARs and point to the importance of postlearning spontaneous circuit activity in memory formation. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Program of China[2011CBA00400]; Chinese Academy of Sciences[KSCX2-YW-R-29]; National Institutes of Health[EY 014979] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1548]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性研究组 |
| 推荐引用方式 GB/T 7714 | Poo, Mu-ming. Postinduction Requirement of NMDA Receptor Activation for Late-Phase Long-Term Potentiation of Developing Retinotectal Synapses In Vivo[J]. JOURNAL OF NEUROSCIENCE,2011,31(9):3328-3335. |
| APA | Poo, Mu-ming.(2011).Postinduction Requirement of NMDA Receptor Activation for Late-Phase Long-Term Potentiation of Developing Retinotectal Synapses In Vivo.JOURNAL OF NEUROSCIENCE,31(9),3328-3335. |
| MLA | Poo, Mu-ming."Postinduction Requirement of NMDA Receptor Activation for Late-Phase Long-Term Potentiation of Developing Retinotectal Synapses In Vivo".JOURNAL OF NEUROSCIENCE 31.9(2011):3328-3335. |
入库方式： OAI收割
来源：上海神经科学研究所
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