Synaptic Mechanisms of Direction Selectivity in Primary Auditory Cortex
文献类型：期刊论文
| 作者 | Poo, Mu-ming
|
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2010 |
| 卷号 | 30期号:5页码:1861-1868 |
| 关键词 | FREQUENCY-MODULATED SWEEPS PRIMARY VISUAL-CORTEX ECHO-LOCATING BATS INFERIOR COLLICULUS UNDERLYING SELECTIVITY RECEPTIVE-FIELDS SIMPLE CELLS COMMUNICATION SOUNDS STIMULUS SELECTIVITY BALANCED INHIBITION |
| ISSN号 | 0270-6474 |
| 通讯作者 | Dan, Y (reprint author), Univ Calif Berkeley, Dept Cell & Mol Biol, Div Neurobiol, Berkeley, CA 94720 USA,ydan@berkeley.edu ; xhzhang@ion.ac.cn |
| 英文摘要 | Frequency modulation (FM) is a prominent feature in animal vocalization and human speech. Although many neurons in the auditory cortex are known to be selective for FM direction, the synaptic mechanisms underlying this selectivity are not well understood. Previous studies of both visual and auditory neurons have suggested two general mechanisms for direction selectivity: (1) differential delays of excitatory inputs across the spatial/spectral receptive field and (2) spatial/spectral offset between excitatory and inhibitory inputs. In this study, we have examined the contributions of both mechanisms to FM direction selectivity in rat primary auditory cortex. The excitatory and inhibitory synaptic inputs to each cortical neuron were measured by in vivo whole-cell recording. The spectrotemporal receptive field of each type of inputs was mapped with random tone pips and compared with direction selectivity of the neuron measured with FM stimuli. We found that both the differential delay of the excitatory input and the spectral offset between excitation and inhibition are positively correlated with direction selectivity of the neuron. Thus, both synaptic mechanisms are likely to contribute to FM direction selectivity in the auditory cortex. Finally, direction selectivity measured from the spiking output is significantly stronger than that based on the subthreshold membrane potentials, indicating that the selectivity is further sharpened by the spike generation mechanism. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | Knowledge Innovation Program of the Chinese Academy of Sciences[KSCX2-YW-R-29]; Major State Basic Research Program of China[2006CB806600]; United States National Institutes of Health |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1618]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性研究组 |
| 推荐引用方式 GB/T 7714 | Poo, Mu-ming. Synaptic Mechanisms of Direction Selectivity in Primary Auditory Cortex[J]. JOURNAL OF NEUROSCIENCE,2010,30(5):1861-1868. |
| APA | Poo, Mu-ming.(2010).Synaptic Mechanisms of Direction Selectivity in Primary Auditory Cortex.JOURNAL OF NEUROSCIENCE,30(5),1861-1868. |
| MLA | Poo, Mu-ming."Synaptic Mechanisms of Direction Selectivity in Primary Auditory Cortex".JOURNAL OF NEUROSCIENCE 30.5(2010):1861-1868. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。