An arithmetic rule for spatial summation of excitatory and inhibitory inputs in pyramidal neurons
文献类型：期刊论文
| 作者 | Poo, Mu-ming
|
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2009 |
| 卷号 | 106期号:51页码:21906-21911 |
| 关键词 | dendrite integration dendritic summation neuronal computation shunting inhibition synaptic physiology DENDRITIC TREE NEURAL-NETWORK CELLS HIPPOCAMPUS OSCILLATIONS TRANSMITTER PROPAGATION COMPUTATION INTEGRATION ACTIVATION |
| ISSN号 | 0027-8424 |
| 通讯作者 | Poo, MM (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,mpoo@berkeley.edu ; xhzhang@ion.ac.cn |
| 英文摘要 | Dendritic integration of excitatory and inhibitory inputs is critical for neuronal computation, but the underlying rules remain to be elucidated. Based on realistic modeling and experiments in rat hippocampal slices, we derived a simple arithmetic rule for spatial summation of concurrent excitatory glutamatergic inputs (E) and inhibitory GABAergic inputs (I). The somatic response can be well approximated as the sum of the excitatory postsynaptic potential (EPSP), the inhibitory postsynaptic potential (IPSP), and a nonlinear term proportional to their product (k*EPSP*IPSP), where the coefficient k reflects the strength of shunting effect. The k value shows a pronounced asymmetry in its dependence on E and I locations. For I on the dendritic trunk, k decays rapidly with E-I distance for proximal Es, but remains largely constant for distal Es, indicating a uniformly high shunting efficacy for all distal Es. For I on an oblique branch, the shunting effect is restricted mainly within the branch, with the same proximal/distal asymmetry. This asymmetry can be largely attributed to cable properties of the dendrite. Further modeling studies showed that this rule also applies to the integration of multiple coincident Es and Is. Thus, this arithmetic rule offers a simple analytical tool for studying E-I integration in pyramidal neurons that incorporates the location specificity of GABAergic shunting inhibition. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 资助信息 | National Institutes of Health[2006CB806600] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1623]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性研究组 |
| 推荐引用方式 GB/T 7714 | Poo, Mu-ming. An arithmetic rule for spatial summation of excitatory and inhibitory inputs in pyramidal neurons[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2009,106(51):21906-21911. |
| APA | Poo, Mu-ming.(2009).An arithmetic rule for spatial summation of excitatory and inhibitory inputs in pyramidal neurons.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,106(51),21906-21911. |
| MLA | Poo, Mu-ming."An arithmetic rule for spatial summation of excitatory and inhibitory inputs in pyramidal neurons".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106.51(2009):21906-21911. |
入库方式： OAI收割
来源：上海神经科学研究所
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