Ca2+-dependent regulation of Rho GTPases triggers turning of nerve growth cones
文献类型：期刊论文
| 作者 | Poo, MM
|
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2005 |
| 卷号 | 25期号:9页码:2338-2347 |
| 关键词 | axon guidance growth cone Rho GTPases calcium PKC CaMKII PROTEIN-KINASE-C SIGNAL-TRANSDUCTION DIFFUSIBLE FACTORS CALCIUM CURRENT NOGO RECEPTOR AXON GUIDANCE ACTIVATION CELLS CDC42 RAC |
| ISSN号 | 0270-6474 |
| 通讯作者 | Poo, MM (reprint author), Univ Calif Berkeley, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA,mpoo@uclink.berkeley.edu ; yuanxb@ion.ac.cn |
| 英文摘要 | Cytoplasmic Ca2+ elevation and changes in Rho GTPase activity are both known to mediate axon guidance by extracellular factors, but the causal relationship between these two events has been unclear. Here we show that direct elevation of cytoplasmic Ca2+ by extracellular application of a low concentration of ryanodine, which activated Ca2+ release from intracellular stores, upregulated Cdc42/Rac, but downregulated RhoA, in cultured cerebellar granule cells and human embryonic kidney 293T cells. Chemoattractive turning of the growth cone triggered by a gradient of ryanodine was blocked by overexpression of mutant forms of Cdc42 but not of RhoA in Xenopus spinal cord neurons. Furthermore, Ca2+-induced GTPase activity correlated with activation of protein kinase C and required a basal activity of Ca2+/calmodulin-dependent protein kinase II. Thus, Rho GTPases may mediate axon guidance by linking upstream Ca2+ signals triggered by guidance factors to downstream cytoskeletal rearrangements. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1916]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性研究组 |
| 推荐引用方式 GB/T 7714 | Poo, MM. Ca2+-dependent regulation of Rho GTPases triggers turning of nerve growth cones[J]. JOURNAL OF NEUROSCIENCE,2005,25(9):2338-2347. |
| APA | Poo, MM.(2005).Ca2+-dependent regulation of Rho GTPases triggers turning of nerve growth cones.JOURNAL OF NEUROSCIENCE,25(9),2338-2347. |
| MLA | Poo, MM."Ca2+-dependent regulation of Rho GTPases triggers turning of nerve growth cones".JOURNAL OF NEUROSCIENCE 25.9(2005):2338-2347. |
入库方式： OAI收割
来源：上海神经科学研究所
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