Contribution of astrocytes to hippocampal long-term potentiation through released D-serine
文献类型：期刊论文
| 作者 | Poo, MM
|
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2003 |
| 卷号 | 100期号:25页码:15194-15199 |
| 关键词 | D-ASPARTATE RECEPTOR NMDA RECEPTORS GLYCINE SITE SYNAPTIC MODIFICATIONS GLUTAMATE TRANSPORT AMINO-ACIDS GLIA NEURONS PLASTICITY BRAIN |
| ISSN号 | 0027-8424 |
| 通讯作者 | Duan, SM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China, |
| 英文摘要 | Repetitive correlated activation of pre- and postsynaptic neurons induced long-term potentiation (LTP) of synaptic transmission among hippocampal neurons grown on a layer of astrocytes (mixed cultures) but not among neurons cultured in glial conditioned medium. Supplement Of D-serine, an agonist for the glycine-binding site of N-methyl-D-aspartate (NMDA) receptors, enhanced NMDA receptor activation and enabled LTP induction in glial conditioned medium cultures. The induction of LTP in both mixed cultures and hippocampal slices was suppressed by NMDA receptor antagonists, glycine-binding-site blockers of NMDA receptors, or an enzyme that degrades endogenous D-serine. By providing extracellular D-serine that facilitates activation of NMDA receptors, astrocytes thus play a key role in long-term synaptic plasticity. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1988]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性研究组 |
| 推荐引用方式 GB/T 7714 | Poo, MM. Contribution of astrocytes to hippocampal long-term potentiation through released D-serine[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2003,100(25):15194-15199. |
| APA | Poo, MM.(2003).Contribution of astrocytes to hippocampal long-term potentiation through released D-serine.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,100(25),15194-15199. |
| MLA | Poo, MM."Contribution of astrocytes to hippocampal long-term potentiation through released D-serine".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100.25(2003):15194-15199. |
入库方式： OAI收割
来源：上海神经科学研究所
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