ATP released by Astrocytes mediates glutamatergic activity-dependent heterosynaptic suppression
文献类型：期刊论文
| 作者 | Poo, MM
|
| 刊名 | NEURON
 |
| 出版日期 | 2003 |
| 卷号 | 40期号:5页码:971-982 |
| 关键词 | RAT SPINAL-CORD DORSAL-HORN NEURONS CALCIUM WAVES HIPPOCAMPAL ASTROCYTES SYNAPTIC TRANSMISSION IN-VITRO RECEPTORS INHIBITION ACTIVATION ADENOSINE |
| ISSN号 | 0896-6273 |
| 通讯作者 | Duan, SM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China, |
| 英文摘要 | Extracellular ATIP released from axons is known to assist activity-dependent signaling between neurons and Schwann cells in the peripheral nervous system. Here we report that ATP released from astrocytes as a result of neuronal activity can also modulate central synaptic transmission. In cultures of hippocampal neurons, endogenously released ATP tonically suppresses glutamatergic synapses via presynaptic P2Y receptors, an effect that depends on the presence of cocultured astrocytes. Glutamate release accompanying neuronal activity also activates non-NMDA receptors of nearby astrocytes and triggers ATIP release from these cells, which in turn causes homo- and heterosynaptic suppression. In CA1 pyramidal neurons of hippocampal slices, a similar synaptic suppression was also produced by adenosine, an immediate degradation product of ATIP released by glial cells. Thus, neuron-glia crosstalk may participate in activity-dependent synaptic modulation. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1989]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性研究组 |
| 推荐引用方式 GB/T 7714 | Poo, MM. ATP released by Astrocytes mediates glutamatergic activity-dependent heterosynaptic suppression[J]. NEURON,2003,40(5):971-982. |
| APA | Poo, MM.(2003).ATP released by Astrocytes mediates glutamatergic activity-dependent heterosynaptic suppression.NEURON,40(5),971-982. |
| MLA | Poo, MM."ATP released by Astrocytes mediates glutamatergic activity-dependent heterosynaptic suppression".NEURON 40.5(2003):971-982. |
入库方式： OAI收割
来源：上海神经科学研究所
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