Bidirectional changes in spatial dendritic integration accompanying long-term synaptic modifications
文献类型：期刊论文
| 作者 | Poo, MM
|
| 刊名 | NEURON
 |
| 出版日期 | 2003 |
| 卷号 | 37期号:3页码:463-472 |
| 关键词 | RAT HIPPOCAMPAL SLICES CA1 PYRAMIDAL NEURONS EPSP-SPIKE POTENTIATION E-S COMPONENT INTRINSIC EXCITABILITY SUPRALINEAR SUMMATION LASTING POTENTIATION PERFORANT PATH K+ CURRENT IN-VITRO |
| ISSN号 | 0896-6273 |
| 通讯作者 | Duan, SM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China, |
| 合作状况 | 国内 |
| 英文摘要 | Information processing in the neuron requires spatial summation of synaptic inputs at the dendrite. In CA1 pyramidal neurons of the hippocampus, a brief period of correlated pre- and postsynaptic activity, which induces long-term potentiation (LTP) or long-term depression (LTD), results in a persistent increase or decrease in the linearity of spatial summation, respectively. Such bidirectional modification of the summation property is specific to the modified input and reflects localized dendritic changes involving I-h channels and NMDA receptors. Thus, correlated pre- and postsynaptic activity alters not only the strength of the activated input but also its dendritic integration with other inputs. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2027]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性研究组 |
| 推荐引用方式 GB/T 7714 | Poo, MM. Bidirectional changes in spatial dendritic integration accompanying long-term synaptic modifications[J]. NEURON,2003,37(3):463-472. |
| APA | Poo, MM.(2003).Bidirectional changes in spatial dendritic integration accompanying long-term synaptic modifications.NEURON,37(3),463-472. |
| MLA | Poo, MM."Bidirectional changes in spatial dendritic integration accompanying long-term synaptic modifications".NEURON 37.3(2003):463-472. |
入库方式： OAI收割
来源：上海神经科学研究所
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