Signalling and crosstalk of Rho GTPases in mediating axon guidance
文献类型：期刊论文
| 作者 | Poo, MM
|
| 刊名 | NATURE CELL BIOLOGY
 |
| 出版日期 | 2003 |
| 卷号 | 5期号:1页码:38-45 |
| 关键词 | MYOSIN-II ACTIVATION GROWTH CONE GUIDANCE NERVE GROWTH FAMILY GTPASES LYSOPHOSPHATIDIC ACID IN-VIVO KINASE PROTEIN PHOSPHORYLATION COLLAPSE |
| ISSN号 | 1465-7392 |
| 通讯作者 | Yuan, XB (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China, |
| 英文摘要 | Axon extension during development of the nervous system is guided by many factors, but the signalling mechanisms responsible for triggering this extension remain mostly unknown. Here we have examined the role of Rho family small guanosine triphosphatases (GTPases) in mediating axon guidance by diffusible factors. Expression of either dominant-negative or constitutively active Cdc42 in cultured Xenopus laevis spinal neurons, at a concentration that does not substantially affect filopodial formation and neurite extension, abolishes the chemoattractive growth cone turning induced by a gradient of brain-derived neurotrophic factor that can activate Cdc42 and Rac in cultured neurons. Chemorepulsion induced by a gradient of lysophosphatidic acid is also abolished by the expression of dominant-negative RhoA. We also show that an asymmetry in Rho kinase or filopodial initiation across the growth cone is sufficient to trigger the turning response and that there is a crosstalk between the Cdc42 and RhoA pathways through their converging actions on the myosin activity essential for growth cone chemorepulsion. |
| 学科主题 | Cell Biology |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-23 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2033]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经可塑性研究组 |
| 推荐引用方式 GB/T 7714 | Poo, MM. Signalling and crosstalk of Rho GTPases in mediating axon guidance[J]. NATURE CELL BIOLOGY,2003,5(1):38-45. |
| APA | Poo, MM.(2003).Signalling and crosstalk of Rho GTPases in mediating axon guidance.NATURE CELL BIOLOGY,5(1),38-45. |
| MLA | Poo, MM."Signalling and crosstalk of Rho GTPases in mediating axon guidance".NATURE CELL BIOLOGY 5.1(2003):38-45. |
入库方式： OAI收割
来源：上海神经科学研究所
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