Short- and Long-Term Plasticity at the Axon Initial Segment
文献类型：期刊论文
| 作者 | Shu, Yousheng
|
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2011 |
| 卷号 | 31期号:45页码:16049-16055 |
| 关键词 | ACTION-POTENTIAL INITIATION 5 PYRAMIDAL NEURONS SODIUM-CHANNELS CALCIUM-CHANNELS NERVOUS-SYSTEM GANGLION-CELLS KV1 CHANNELS ANKYRIN-G EXCITABILITY MECHANISM |
| ISSN号 | 0270-6474 |
| 通讯作者 | Grubb, MS (reprint author), Kings Coll London, MRC Ctr Dev Neurobiol, London SE1 1UL, England,matthew.grubb@kcl.ac.uk ; kbender@gallo.ucsf.edu |
| 英文摘要 | The axon initial segment (AIS) is a highly specialized neuronal subregion that is the site of action potential initiation and the boundary between axonal and somatodendritic compartments. In recent years, our understanding of the molecular structure of the AIS, its maturation, and its multiple fundamental roles in neuronal function has seen major advances. We are beginning to appreciate that the AIS is dynamically regulated, both over short timescales via adaptations in ion channel function, and long timescales via activity-dependent structural reorganization. Here, we review results from this emerging field highlighting how structural and functional plasticity relate to the development of the initial segment, and to neuronal disorders linked to AIS dysfunction. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | Wellcome Trust; 973 Program[2011CBA00400, 2006CB806600]; National Natural Science Foundation of China[31025012]; Ministry of Education, Culture, Sports, Science, and Technology[22680032]; Japan Science and Technology Agency; NIH[NS044916, NS069688, DC011080]; state of California through University of California, San Francisco |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1524]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经网络功能研究组 |
| 推荐引用方式 GB/T 7714 | Shu, Yousheng. Short- and Long-Term Plasticity at the Axon Initial Segment[J]. JOURNAL OF NEUROSCIENCE,2011,31(45):16049-16055. |
| APA | Shu, Yousheng.(2011).Short- and Long-Term Plasticity at the Axon Initial Segment.JOURNAL OF NEUROSCIENCE,31(45),16049-16055. |
| MLA | Shu, Yousheng."Short- and Long-Term Plasticity at the Axon Initial Segment".JOURNAL OF NEUROSCIENCE 31.45(2011):16049-16055. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。