Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex
文献类型：期刊论文
| 作者 | Hu, Hailan
|
| 刊名 | SCIENCE
 |
| 出版日期 | 2011 |
| 卷号 | 334期号:6056页码:693-697 |
| 关键词 | AMPA RECEPTOR TRAFFICKING DOMINANCE MICE PLASTICITY RATS ENVIRONMENT MODULATION BEHAVIOR MOUSE RAS |
| ISSN号 | 0036-8075 |
| 通讯作者 | Hu, HL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,hailan@ion.ac.cn |
| 合作状况 | 国内 |
| 英文摘要 | Dominance hierarchy has a profound impact on animals' survival, health, and reproductive success, but its neural circuit mechanism is virtually unknown. We found that dominance ranking in mice is transitive, relatively stable, and highly correlates among multiple behavior measures. Recording from layer V pyramidal neurons of the medial prefrontal cortex (mPFC) showed higher strength of excitatory synaptic inputs in mice with higher ranking, as compared with their subordinate cage mates. Furthermore, molecular manipulations that resulted in an increase and decrease in the synaptic efficacy in dorsal mPFC neurons caused an upward and downward movement in the social rank, respectively. These results provide direct evidence for mPFC's involvement in social hierarchy and suggest that social rank is plastic and can be tuned by altering synaptic strength in mPFC pyramidal cells. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 资助信息 | Chinese 973 Program[2011CBA00400]; Scientific Research Foundation; Hundreds of Talents Program; Shanghai Pujiang Talent Program |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1525]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经环路与行为可塑性研究组 |
| 推荐引用方式 GB/T 7714 | Hu, Hailan. Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex[J]. SCIENCE,2011,334(6056):693-697. |
| APA | Hu, Hailan.(2011).Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex.SCIENCE,334(6056),693-697. |
| MLA | Hu, Hailan."Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex".SCIENCE 334.6056(2011):693-697. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。