Lgl1 Activation of Rab10 Promotes Axonal Membrane Trafficking Underlying Neuronal Polarization
文献类型：期刊论文
| 作者 | Luo, Zhen-Ge
|
| 刊名 | DEVELOPMENTAL CELL
 |
| 出版日期 | 2011 |
| 卷号 | 21期号:3页码:431-444 |
| 关键词 | LETHAL-GIANT-LARVAE NEURITE OUTGROWTH PLASMA-MEMBRANE GLUT4 TRANSLOCATION HIPPOCAMPAL-NEURONS EXOCYST COMPLEX MUSCLE-CELLS SAD KINASES POLARITY GTPASES |
| ISSN号 | 1534-5807 |
| 通讯作者 | Luo, ZG (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,zgluo@ion.ac.cn |
| 英文摘要 | Directed membrane trafficking is believed to be crucial for axon development during neuronal morphogenesis. However, the underlying mechanisms are poorly understood. Here, we report a role of Lgl1, the mammalian homolog of Drosophila tumor suppressor Lethal giant larvae, in controlling membrane trafficking underlying axonal growth. We find that Lgl1 is associated with plasmalemmal precursor vesicles and enriched in developing axons. Lgl1 upregulation promoted axonal growth, whereas downregulation attenuated it as well as directional membrane insertion. Interestingly, Lgl1 interacted with and activated Rab10, a small GTPase that mediates membrane protein trafficking, by releasing GDP dissociation inhibitor (GDI) from Rab10. Furthermore, Rab10 lies downstream of Lgl1 in axon development and directional membrane insertion. Finally, both Lgl1 and Rab10 are required for neocortical neuronal polarization in vivo. Thus, the Lgl1 regulation of Rab10 stimulates the trafficking of membrane precursor vesicles, whose fusion with the plasmalemma is crucial for axonal growth. |
| 学科主题 | Cell Biology ; Developmental Biology |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Program[2011CB809002]; Chinese Academy of Sciences[XDA01020305]; National Natural Science Foundation of China[31021063, 30825013] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1527]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_突触信号研究组 |
| 推荐引用方式 GB/T 7714 | Luo, Zhen-Ge. Lgl1 Activation of Rab10 Promotes Axonal Membrane Trafficking Underlying Neuronal Polarization[J]. DEVELOPMENTAL CELL,2011,21(3):431-444. |
| APA | Luo, Zhen-Ge.(2011).Lgl1 Activation of Rab10 Promotes Axonal Membrane Trafficking Underlying Neuronal Polarization.DEVELOPMENTAL CELL,21(3),431-444. |
| MLA | Luo, Zhen-Ge."Lgl1 Activation of Rab10 Promotes Axonal Membrane Trafficking Underlying Neuronal Polarization".DEVELOPMENTAL CELL 21.3(2011):431-444. |
入库方式： OAI收割
来源：上海神经科学研究所
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