Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function
文献类型：期刊论文
| 作者 | Wu, Dongmei ; Qiu, Yifu ; Gao, Xiang ; Yuan, Xiao-Bing ; Zhai, Qiwei |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2011 |
| 卷号 | 6期号:6页码:e21759-e21760 |
| 关键词 | SIGNAL-REGULATED KINASE PANCREATIC BETA-CELLS CALORIE RESTRICTION SYNAPTIC PLASTICITY MITOCHONDRIAL-FUNCTION INSULIN SENSITIVITY ENERGY-METABOLISM THYROID-HORMONE PPAR-GAMMA MICE SHOW |
| ISSN号 | 1932-6203 |
| 通讯作者 | Wu, DM (reprint author), Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci,Grad Sch, Shanghai, Peoples R China,qwzhai@sibs.ac.cn |
| 英文摘要 | SIRT1 plays crucial roles in glucose and lipid metabolism, and has various functions in different tissues including brain. The brain-specific SIRT1 knockout mice display defects in somatotropic signaling, memory and synaptic plasticity. And the female mice without SIRT1 in POMC neuron are more sensitive to diet-induced obesity. Here we created transgenic mice overexpressing SIRT1 in striatum and hippocampus under the control of CaMKII alpha promoter. These mice, especially females, exhibited increased fat accumulation accompanied by significant upregulation of adipogenic genes in white adipose tissue. Glucose tolerance of the mice was also impaired with decreased Glut4 mRNA levels in muscle. Moreover, the SIRT1 overexpressing mice showed decreased energy expenditure, and concomitantly mitochondria-related genes were decreased in muscle. In addition, these mice showed unusual spontaneous physical activity pattern, decreased activity in open field and rotarod performance. Further studies demonstrated that SIRT1 deacetylated IRS-2, and upregulated phosphorylation level of IRS-2 and ERK1/2 in striatum. Meanwhile, the neurotransmitter signaling in striatum and the expression of endocrine hormones in hypothalamus and serum T3, T4 levels were altered. Taken together, our findings demonstrate that SIRT1 in forebrain regulates lipid/glucose metabolism and motor function. |
| 学科主题 | Life Sciences & Biomedicine - Other Topics |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[30825009, 30970619, 31030022, 81021002]; National Basic Research Program of China (973 Program)[2009CB918403, 2007CB914501, 2006CB503900]; Chinese Academy of Sciences[KSCX1-YW-02]; Director Foundation of Institute for Nutritional Sciences[20090101]; SA-SIBS |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1536]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Wu, Dongmei,Qiu, Yifu,Gao, Xiang,et al. Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function[J]. PLOS ONE,2011,6(6):e21759-e21760. |
| APA | Wu, Dongmei,Qiu, Yifu,Gao, Xiang,Yuan, Xiao-Bing,&Zhai, Qiwei.(2011).Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function.PLOS ONE,6(6),e21759-e21760. |
| MLA | Wu, Dongmei,et al."Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function".PLOS ONE 6.6(2011):e21759-e21760. |
入库方式： OAI收割
来源：上海神经科学研究所
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