MiR-125b targets BCL3 and suppresses ovarian cancer proliferation
文献类型：期刊论文
| 作者 | Guan, Yi ; Yao, Hailan ; Zheng, Zhihong ; Qiu, Guangrong ; Sun, Kailai |
| 刊名 | INTERNATIONAL JOURNAL OF CANCER
 |
| 出版日期 | 2011 |
| 卷号 | 128期号:10页码:2274-2283 |
| 关键词 | miR-125b ovarian cancer proliferation BCL3 MICRORNA EXPRESSION PROFILES CELL-PROLIFERATION SURVIVAL STIMULATION MALIGNANCY RESISTANCE APOPTOSIS ROLES |
| ISSN号 | 0020-7136 |
| 通讯作者 | Sun, KL (reprint author), China Med Univ, Dept Med Genet, Shenyang 110001, Peoples R China,klsun@mail.cmu.edu.cn |
| 英文摘要 | Micro-RNAs (miRNAs) important for post-transcriptional gene expression as negative regulators are endogenous 21- to 23-nucleotide noncoding RNAs. Many miRNAs are expressed in ovarian cancer (OC). In this study, we reported that miR-125b was underexpressed in human OC specimens. Ectopic expression of miR-125b in OC cells induced cell cycle arrest and led to reduction in proliferation and clonal formation. This inhibitory effect on OC cell growth was mediated by miR-125b inhibition of the translation of an mRNA encoding a proto-oncogene, BCL3. Furthermore, expression of miR-125b suppressed the tumor formation generated by injecting OC cells in nude mice. Our results suggest that aberrantly expressed miR-125b may contribute to OC development. |
| 学科主题 | Oncology |
| 收录类别 | SCI |
| 资助信息 | NNSF of China[30571836] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1541]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Guan, Yi,Yao, Hailan,Zheng, Zhihong,et al. MiR-125b targets BCL3 and suppresses ovarian cancer proliferation[J]. INTERNATIONAL JOURNAL OF CANCER,2011,128(10):2274-2283. |
| APA | Guan, Yi,Yao, Hailan,Zheng, Zhihong,Qiu, Guangrong,&Sun, Kailai.(2011).MiR-125b targets BCL3 and suppresses ovarian cancer proliferation.INTERNATIONAL JOURNAL OF CANCER,128(10),2274-2283. |
| MLA | Guan, Yi,et al."MiR-125b targets BCL3 and suppresses ovarian cancer proliferation".INTERNATIONAL JOURNAL OF CANCER 128.10(2011):2274-2283. |
入库方式： OAI收割
来源：上海神经科学研究所
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