A model study on the circuit mechanism underlying decision-making in Drosophila
文献类型：期刊论文
| 作者 | Wu, Zhihua ; Guo, Aike |
| 刊名 | NEURAL NETWORKS
 |
| 出版日期 | 2011 |
| 卷号 | 24期号:4页码:333-344 |
| ISSN号 | 0893-6080 |
| 关键词 | Systems-level circuit model Drosophila Decision-making Dopamine modulation Attention Feature binding VISUAL-PATTERN MEMORY MUSHROOM BODY NEURONS PREFRONTAL CORTEX DOPAMINERGIC-NEURONS WORKING-MEMORY NETWORK MODEL OLFACTORY SYSTEM MODULATION RECEPTOR BRAIN |
| 通讯作者 | Wu, ZH (reprint author), Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, 15 Datun Rd, Beijing 100101, Peoples R China,wuzh@moon.ibp.ac.cn ; akguo@ion.ac.cn |
| 英文摘要 | Previous elegant experiments in a flight simulator showed that conditioned Drosophila is able to make a clear-cut decision to avoid potential danger. When confronted with conflicting visual cues, the relative saliency of two competing cues is found to be a sensory ruler for flies to judge which cue should be used for decision-making. Further genetic manipulations and immunohistological analysis revealed that the dopamine system and mushroom bodies are indispensable for such a clear-cut or nonlinear decision. The neural circuit mechanism, however, is far from being clear. In this paper, we adopt a computational modeling approach to investigate how different brain areas and the dopamine system work together to drive a fly to make a decision. By developing a systems-level neural network, a two-pathway circuit is proposed. Besides a direct pathway from a feature binding area to the motor center, another connects two areas via the mushroom body, a target of dopamine release. A raised dopamine level is hypothesized to be induced by complex choice tasks and to enhance lateral inhibition and steepen the units' response gain in the mushroom body. Simulations show that training helps to assign values to formerly neutral features. For a circuit model with a blocked mushroom body, the direct pathway passes all alternatives to the motor center without changing original values, giving rise to a simple choice characterized by a linear choice curve. With respect to an intact circuit, enhanced lateral inhibition dependent on dopamine critically promotes competition between alternatives, turning the linear-into nonlinear choice behavior. Results account well for experimental data, supporting the reasonableness of model working hypotheses. Several testable predictions are made for future studies. (C) 2011 Elsevier Ltd. All rights reserved. |
| 学科主题 | Computer Science ; Neurosciences & Neurology |
| 资助信息 | National Science Foundation of China[30770495, 30630028, 90820008, 30770511, 30921064]; Chinese Academy of Sciences[KSCX2-YW-R-39, KSCX2-YW-R-247] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1542]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Wu, Zhihua,Guo, Aike. A model study on the circuit mechanism underlying decision-making in Drosophila[J]. NEURAL NETWORKS,2011,24(4):333-344. |
| APA | Wu, Zhihua,&Guo, Aike.(2011).A model study on the circuit mechanism underlying decision-making in Drosophila.NEURAL NETWORKS,24(4),333-344. |
| MLA | Wu, Zhihua,et al."A model study on the circuit mechanism underlying decision-making in Drosophila".NEURAL NETWORKS 24.4(2011):333-344. |
入库方式： OAI收割
来源：上海神经科学研究所
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