ASIC3 Channels in Multimodal Sensory Perception
文献类型：期刊论文
| 作者 | Li, Wei-Guang ; Xu, Tian-Le(徐天乐) |
| 刊名 | ACS CHEMICAL NEUROSCIENCE
 |
| 出版日期 | 2011 |
| 卷号 | 2期号:1页码:26-37 |
| 关键词 | Acid-sensing ion channel ASIC3 nonproton ligand nociception mechanosensation chemosensation SENSING ION CHANNELS PROTON-GATED CHANNELS ACID-EVOKED CURRENTS DORSAL-ROOT GANGLIA CATION CHANNEL MUSCLE INFLAMMATION MYOCARDIAL-ISCHEMIA MOLECULAR-CLONING NA+ CHANNEL IN-VIVO |
| ISSN号 | 1948-7193 |
| 通讯作者 | Xu, TL (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn |
| 英文摘要 | Acid-sensing ion channels (ASICs), which are members of the sodium-selective cation channels belonging to the epithelial sodium channel/degenerin (ENaC/DEG) family, act as membrane-bound receptors for extracellular protons as well as nonproton ligands. At least five ASIC subunits have been identified in mammalian neurons, which form both homotrimeric and heterotrimeric channels. The highly proton sensitive ASIC3 channels are predominantly distributed in peripheral sensory neurons, correlating with their roles in multimodal sensory perception, including nociception, mechanosensation, and chemosensation. Different from other ASIC subunit composing ion channels, ASIC3 channels can mediate a sustained window current in response to mild extracellular acidosis (pH 7.3-6.7), which often occurs accompanied by many sensory stimuli. Furthermore, recent evidence indicates that the sustained component of ASIC3 currents can be enhanced by nonproton ligands including the endogenous metabolite agmatine. In this review, we first summarize the growing body of evidence for the involvement of ASIC3 channels in multimodal sensory perception and then discuss the potential mechanisms underlying ASIC3 activation and mediation of sensory perception, with a special emphasis on its role in nociception. We conclude that ASIC3 activation and modulation by diverse sensory stimuli represent a new avenue for understanding the role of ASIC3 channels in sensory perception. Furthermore, the emerging implications of ASIC3 channels in multiple sensory dysfunctions including nociception allow the development of new pharmacotherapy. |
| 学科主题 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[30830035]; National Basic Research Program of China[2011CB809000]; Shanghai Municipal Government[09XD1404900] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1559]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Li, Wei-Guang,Xu, Tian-Le. ASIC3 Channels in Multimodal Sensory Perception[J]. ACS CHEMICAL NEUROSCIENCE,2011,2(1):26-37. |
| APA | Li, Wei-Guang,&Xu, Tian-Le.(2011).ASIC3 Channels in Multimodal Sensory Perception.ACS CHEMICAL NEUROSCIENCE,2(1),26-37. |
| MLA | Li, Wei-Guang,et al."ASIC3 Channels in Multimodal Sensory Perception".ACS CHEMICAL NEUROSCIENCE 2.1(2011):26-37. |
入库方式： OAI收割
来源：上海神经科学研究所
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