Regulation of beta cleavage of amyloid precursor protein
文献类型：期刊论文
| 作者 | Wang, Jun-Feng ; Lu, Rui ; Wang, Yi-Zheng |
| 刊名 | NEUROSCIENCE BULLETIN
 |
| 出版日期 | 2010 |
| 卷号 | 26期号:5页码:417-427 |
| 关键词 | Alzheimer's disease amyloid beta peptide amyloid precursor protein beta secretase APP TRANSGENIC MICE ALZHEIMERS-DISEASE A-BETA SECRETASE ACTIVITY PLAQUE-FORMATION GAMMA-SECRETASE GENE-EXPRESSION IN-VIVO BACE1 BRAIN |
| ISSN号 | 1673-7067 |
| 通讯作者 | Wang, YZ (reprint author), Shanghai Inst Biol Sci, Inst Neurosci, Lab Neural Signal Transduct, State Key Lab Neurosci, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn |
| 英文摘要 | Alzheimer's disease ranks the first cause for senile dementia. The amyloid cascade is proposed to contribute to the pathogenesis of this disease. In this cascade, amyloid beta peptide (A beta) is produced through a sequential cleavage of amyloid precursor protein (APP) by beta and gamma secretases, while its cleavage by alpha secretase precludes A beta production and generates neurotrophic sAPP alpha. Thus, enhancing alpha secretase activity or suppressing beta and gamma cleavage may reduce A beta formation and ameliorate the pathological process of the disease. Several regulatory mechanisms of APP cleavage have been established. The present review mainly summarizes the signaling pathways pertinent to the regulation of APP beta cleavage. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[30711120566] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1573]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Wang, Jun-Feng,Lu, Rui,Wang, Yi-Zheng. Regulation of beta cleavage of amyloid precursor protein[J]. NEUROSCIENCE BULLETIN,2010,26(5):417-427. |
| APA | Wang, Jun-Feng,Lu, Rui,&Wang, Yi-Zheng.(2010).Regulation of beta cleavage of amyloid precursor protein.NEUROSCIENCE BULLETIN,26(5),417-427. |
| MLA | Wang, Jun-Feng,et al."Regulation of beta cleavage of amyloid precursor protein".NEUROSCIENCE BULLETIN 26.5(2010):417-427. |
入库方式： OAI收割
来源：上海神经科学研究所
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