Glycine and glycine receptor signaling in hippocampal neurons: Diversity, function and regulation
文献类型：期刊论文
| 作者 | Xu, Tian-Le(徐天乐) ; Gong, Neng |
| 刊名 | PROGRESS IN NEUROBIOLOGY
 |
| 出版日期 | 2010 |
| 卷号 | 91期号:4页码:349-361 |
| 关键词 | Glycine Glycine receptor NMDA receptor Hippocampus Homeostatic regulation DORSAL COMMISSURAL NEURONS D-ASPARTATE RECEPTOR PROTEIN-KINASE-C ACTIVATED CHLORIDE CURRENTS TRANSPORTER SUBTYPE 1B SUBUNIT MESSENGER-RNAS SPINAL-CORD NEURONS RAT HIPPOCAMPAL NMDA RECEPTOR D-SERINE |
| ISSN号 | 0301-0082 |
| 通讯作者 | Xu, TL (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn |
| 英文摘要 | Glycine is a primary inhibitory neurotransmitter in the spinal cord and brainstem. It acts at glycine receptor (GlyR)-chloride channels, as well as a co-agonist of NMDA receptors (NMDARs). In the hippocampus, the study of GlyRs has largely been under-appreciated due to the apparent absence of glycinergic synaptic transmission. Emerging evidence has shown the presence of extrasynaptic GlyRs in the hippocampus, which exert a tonic inhibitory role, and can be highly regulated under many pathophysiological conditions. On the other hand, besides D-serine, glycine has also been shown to modulate NMDAR function in the hippocampus. The simultaneous activation of excitatory NMDARs and inhibitory GlyRs may provide a homeostatic regulation of hippocampal network function. Furthermore, glycine can regulate hippocampal neuronal activity through GlyR-mediated cross-inhibition of GABAergic inhibition, or through the glycine binding site-dependent internalization of NMDARs. Therefore, hippocampal glycine and its receptors may operate in concert to finely regulate hippocampus-dependent high brain function such as learning and memory. Finally, dysfunction of hippocampal glycine signaling is associated with neuropsychiatric disorders. We speculate that further studies of hippocampal glycine-mediated regulation may help develop novel glycine-based approaches for therapeutic developments. (C) 2010 Elsevier Ltd. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China[30830035]; National Basic Research Program of China[2006CB500803]; Chinese Academy of Sciences[KSCX2-YW-R-35]; Shanghai Municipal Government[09XD1404900] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1583]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Xu, Tian-Le,Gong, Neng. Glycine and glycine receptor signaling in hippocampal neurons: Diversity, function and regulation[J]. PROGRESS IN NEUROBIOLOGY,2010,91(4):349-361. |
| APA | Xu, Tian-Le,&Gong, Neng.(2010).Glycine and glycine receptor signaling in hippocampal neurons: Diversity, function and regulation.PROGRESS IN NEUROBIOLOGY,91(4),349-361. |
| MLA | Xu, Tian-Le,et al."Glycine and glycine receptor signaling in hippocampal neurons: Diversity, function and regulation".PROGRESS IN NEUROBIOLOGY 91.4(2010):349-361. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。