Functional feedback from mushroom bodies to antennal lobes in the Drosophila olfactory pathway
文献类型：期刊论文
| 作者 | Wang, Zuoren
|
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2010 |
| 卷号 | 107期号:22页码:10262-10267 |
| 关键词 | ODOR REPRESENTATIONS MEMORY TRACE ION CHANNELS NEURONS BODY PROJECTIONS MELANOGASTER RECEPTORS HONEYBEE BULB |
| ISSN号 | 0027-8424 |
| 通讯作者 | Wang, ZR (reprint author), Chinese Acad Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China,zuorenwang@ion.ac.cn |
| 英文摘要 | Feedback plays important roles in sensory processing. Mushroom bodies are believed to be involved in olfactory learning/memory and multisensory integration in insects. Previous cobalt-labeling studies have suggested the existence of feedback from the mushroom bodies to the antennal lobes in the honey bee. In this study, the existence of functional feedback from Drosophila mushroom bodies to the antennal lobes was investigated through ectopic expression of the ATP receptor P2X(2) in the Kenyon cells of mushroom bodies. Activation of Kenyon cells induced depolarization in projection neurons and local interneurons in the antennal lobes in a nicotinic receptor-dependent manner. Activation of Kenyon cell axons in the beta gamma-lobes in the mushroom body induced more potent responses in the antennal lobe neurons than activation of Kenyon cell somata. Our results indicate that functional feedback from Kenyon cells to projection neurons and local interneurons is present in Drosophila and is likely mediated by the beta gamma-lobes. The presence of this functional feedback from the mushroom bodies to the antennal lobes suggests top-down modulation of olfactory information processing in Drosophila. |
| 学科主题 | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 资助信息 | Chinese Academy of Sciences[KSCX1-YW-R-31]; China Postdoctoral Foundation[20080430704]; Shanghai Postdoctoral Fund[07R214155]; [973-2006CB806604]; [NSF30625020]; [NSF30621062] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1590]  |
| 专题 | 上海神经科学研究所_神经所(总) 上海神经科学研究所_神经环路与动物行为研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Zuoren. Functional feedback from mushroom bodies to antennal lobes in the Drosophila olfactory pathway[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2010,107(22):10262-10267. |
| APA | Wang, Zuoren.(2010).Functional feedback from mushroom bodies to antennal lobes in the Drosophila olfactory pathway.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(22),10262-10267. |
| MLA | Wang, Zuoren."Functional feedback from mushroom bodies to antennal lobes in the Drosophila olfactory pathway".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107.22(2010):10262-10267. |
入库方式： OAI收割
来源：上海神经科学研究所
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