DEFECTS OF SYNAPTIC VESICLE TURNOVER AT EXCITATORY AND INHIBITORY SYNAPSES IN NIEMANN-PICK C1-DEFICIENT NEURONS
文献类型：期刊论文
| 作者 | Xu, S. ; Zhou, S. ; Xia, D. ; Xia, J. ; Chen, G. ; Duan, S. ; Luo, J. |
| 刊名 | NEUROSCIENCE
 |
| 出版日期 | 2010 |
| 卷号 | 167期号:3页码:608-620 |
| 关键词 | cholesterol synaptic vesicle recycling readily releasable pool spine READILY RELEASABLE POOL CULTURED HIPPOCAMPAL-NEURONS C-DISEASE NERVE-TERMINALS DISTAL AXONS CELL-BODIES CHOLESTEROL PROTEIN PLASTICITY NEURODEGENERATION |
| ISSN号 | 0306-4522 |
| 通讯作者 | Luo, J (reprint author), Zhejiang Univ, Sch Med, Inst Neurosci, Dept Neurobiol, 388 Yu Hangtang St, Hangzhou 310058, Zhejiang, Peoples R China,luojianhong@zju.edu.cn |
| 英文摘要 | Niemann-Pick disease type C (NPC) is a progressive neurodegenerative disorder characterized by accumulation of free cholesterol in late endosomes/lysosomes. The pathological basis for the disease is poorly understood. In the present study, electrophysiological and fluorescent dye studies were applied to examine neuron-specific functions of Niemann-Pick disease type Cl (NPC1) and to determine whether excitatory and inhibitory synapses are differentially impaired by NPC1 deficiency. Densities of spines and postsynaptic receptor clusters were not affected by NPC1 deficiency over the period examined. However, drastic defects on exocytosis were found both in glutamatergic and GABAergic synapses. The defects were caused in part by a delay in the time required for replacement of excytosed vesicles with new fusion-competent ones. Moreover, we found that the delay of synaptic vesicle turnover was longer in inhibitory synapses (>3 s) than in excitatory synapses (<0.2 s). These defects may be early indicators, and could provide a potential explanation for key features of the disease, such as dystonia and seizures. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 收录类别 | SCI |
| 资助信息 | Major State Basic Research Program of China[2010CB912002]; National Natural Science Foundation of China[30900430, 30730038]; Zhejiang Provincial Natural Science Foundation[Y2080208]; Scientific Research Fund of Zhejiang Provincial Education Department[Y200803366]; Ningbo Natural Science Foundation[2009A610119]; Talent Project of Ningbo University[RCL2008008]; Scientific Research Fund[xkl09125]; K. C. Wong Magna Fund of Ningbo University |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1592]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Xu, S.,Zhou, S.,Xia, D.,et al. DEFECTS OF SYNAPTIC VESICLE TURNOVER AT EXCITATORY AND INHIBITORY SYNAPSES IN NIEMANN-PICK C1-DEFICIENT NEURONS[J]. NEUROSCIENCE,2010,167(3):608-620. |
| APA | Xu, S..,Zhou, S..,Xia, D..,Xia, J..,Chen, G..,...&Luo, J..(2010).DEFECTS OF SYNAPTIC VESICLE TURNOVER AT EXCITATORY AND INHIBITORY SYNAPSES IN NIEMANN-PICK C1-DEFICIENT NEURONS.NEUROSCIENCE,167(3),608-620. |
| MLA | Xu, S.,et al."DEFECTS OF SYNAPTIC VESICLE TURNOVER AT EXCITATORY AND INHIBITORY SYNAPSES IN NIEMANN-PICK C1-DEFICIENT NEURONS".NEUROSCIENCE 167.3(2010):608-620. |
入库方式： OAI收割
来源：上海神经科学研究所
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