The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons
文献类型：期刊论文
| 作者 | Li, Ning ; Zhao, Chun-Tao ; Wang, Ying ; Yuan, Xiao-Bing |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2010 |
| 卷号 | 5期号:5页码:e10596-e10597 |
| 关键词 | CCAAT DISPLACEMENT PROTEIN CELL-CYCLE EXIT HOMEODOMAIN PROTEIN HOMEOBOX GENE CEREBRAL-CORTEX RHO-GTPASES P27(KIP1) EXPRESSION SUBVENTRICULAR ZONE TRANSGENIC MICE DROSOPHILA CUT |
| ISSN号 | 1932-6203 |
| 通讯作者 | Li, N (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China,yuanxb@ion.ac.cn |
| 英文摘要 | In the murine cerebral cortex, mammalian homologues of the Cux family transcription factors, Cux1 and Cux2, have been identified as restricted molecular markers for the upper layer (II-IV) pyramidal neurons. However, their functions in cortical development are largely unknown. Here we report that increasing the intracellular level of Cux1, but not Cux2, reduced the dendritic complexity of cultured cortical pyramidal neurons. Consistently, reducing the expression of Cux1 promoted the dendritic arborization in these pyramidal neurons. This effect required the existence of the DNA-binding domains, hence the transcriptional passive repression activity of Cux1. Analysis of downstream signals suggested that Cux1 regulates dendrite development primarily through suppressing the expression of the cyclin-dependent kinase inhibitor p27(Kip1), and RhoA may mediate the regulation of dendritic complexity by Cux1 and p27. Thus, Cux1 functions as a negative regulator of dendritic complexity for cortical pyramidal neurons. |
| 学科主题 | Life Sciences & Biomedicine - Other Topics |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Program of China[2006CB943903]; National Natural Science Foundation of China[30625023]; Chinese Academy of Sciences[KSCX2-YW-R-103] |
| 语种 | 英语 |
| 公开日期 | 2012-07-13 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/1593]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Li, Ning,Zhao, Chun-Tao,Wang, Ying,et al. The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons[J]. PLOS ONE,2010,5(5):e10596-e10597. |
| APA | Li, Ning,Zhao, Chun-Tao,Wang, Ying,&Yuan, Xiao-Bing.(2010).The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons.PLOS ONE,5(5),e10596-e10597. |
| MLA | Li, Ning,et al."The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons".PLOS ONE 5.5(2010):e10596-e10597. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。